Results 21 to 30 of about 342,327 (294)
An Overview of Liquid-Liquid Phase Separation and Its Mechanisms in Sepsis [PDF]
Journal of Inflammation ResearchMeiling Cao,1,* Xinyi Zhang,2,* Xiaohan Wang,2,* Danyang Zhao,2 Mingyue Shi,2 Jiahui Zou,2 Lei Li,3 Hongkun Jiang2 1Department of Neonatology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ...
Cao M +7 more
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Liquid–Liquid Phase Separation in Crowded Environments [PDF]
International Journal of Molecular Sciences, 2020 Biomolecular condensates play a key role in organizing cellular fluids such as the cytoplasm and nucleoplasm. Most of these non-membranous organelles show liquid-like properties both in cells and when studied in vitro through liquid–liquid phase separation (LLPS) of purified proteins.
Alain A. M. André, Evan Spruijt
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Liquid–liquid phase separation within fibrillar networks
Nature Communications, 2023 Complex fibrillar networks mediate liquid–liquid phase separation of biomolecular condensates within the cell. Mechanical interactions between these condensates and the surrounding networks are increasingly implicated in the physiology of the condensates
Jason X. Liu +5 more
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Does Liquid-Liquid Phase Separation Drive Peptide Folding? [PDF]
, 2020 Proline-arginine (PR) dipeptide repeats have been shown to undergo liquid-liquid phase separation and are an example of a growing number of intrinsically disordered proteins that can assemble into membraneless organelles.
Meredith R., Flanagan +2 more
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Liquid–liquid phase separation in autophagy
Journal of Cell Biology, 2020 Liquid–liquid phase separation (LLPS) compartmentalizes and concentrates biomacromolecules into distinct condensates. Liquid-like condensates can transition into gel and solid states, which are essential for fulfilling their different functions. LLPS plays important roles in multiple steps of autophagy, mediating the assembly of autophagosome formation
Nobuo N. Noda, Zheng Wang, Hong Zhang
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When liquid-liquid phase separation meets viral infections
Frontiers in Immunology, 2022 Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown.
Wenqiang Wei +10 more
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Liquid–liquid phase separation in artificial cells [PDF]
Interface Focus, 2018 Abstract Liquid–liquid phase separation (LLPS) in biology is a recently appreciated means of intracellular compartmentalization. Because the mechanisms driving phase separations are grounded in physical interactions, they can be recreated within less complex systems consisting of only a few simple components, to serve as artificial ...
Charles D. Crowe, Christine D. Keating
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Designer Compartment for Artificial Metalloenzymes through Controlled Liquid-Liquid Phase Separation [PDF]
, 2021 Artificial metalloenzymes with different protein scaffolds, cofactors and functions have been prepared to expand the natural enzymatic repertoire with abiotic reactions.
Guopu, Huang +6 more
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Targeting viral liquid–liquid phase separation [PDF]
Nature Reviews Microbiology, 2021 Two recent studies provide evidence that liquid–liquid phase separation during viral replication is a target for antiviral therapy.
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Cells, 2022 Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes.
Klizia Maccaroni +3 more
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