LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
Life Science Alliance, 2023 This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
Bing Zhao +17 more
doaj +1 more source
A novel separation technique: Gas-assisted three-liquid-phase extraction for treatment of the phenolic wastewater [PDF]
, 2010 A novel technique, gas-assisted three-liquid-phase extraction (GATE), was proposed to improve three-liquid-phase separation of p-nitrophenol (p-NP) and o-nitrophenol (o-NP) from wastewater.
Deng, Fuli +14 more
core +1 more source
Liquid-liquid phase separation and viscosity in biomass burning organic aerosol and climatic impacts [PDF]
, 2023 Smoke particles generated by burning biomass consist mainly of organic aerosol, referred to as biomass-burning organic aerosol (BBOA). BBOA influences the climate by scattering and absorbing solar radiation or acting as nuclei for cloud formation.
Nealan G. A., Gerrebos +10 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Advanced modelling and visualisation of liquid-liquid separations of complex sample components, with variable phase distribution and mode of operation [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research is about liquid-liquid chromatography modelling.
De Folter, Jozefus Johannes Martinus
core
Kinetics of hydroformylation of 1-octene in ionic liquid-organic biphasic media using rhodium sulfoxantphos catalyst [PDF]
, 2011 Biphasic hydroformylation of 1-octene was performed using rhodium sulfoxantphos catalyst dissolved in [BuPy][BF4] ionic liquid. Preliminary experiments proved this system to retain the catalytic complex within the ionic liquid phase and to maintain a ...
Kelkar, Ashutosh A. +9 more
core +1 more source
Evidence for and against Liquid-Liquid Phase Separation in the Nucleus [PDF]
Non-Coding RNA, 2019 Enclosed by two membranes, the nucleus itself is comprised of various membraneless compartments, including nuclear bodies and chromatin domains. These compartments play an important though still poorly understood role in gene regulation. Significant progress has been made in characterizing the dynamic behavior of nuclear compartments and liquid-liquid ...
Peng A, Stephanie C. Weber
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Novel liquid phase separation techniques for proteome study [PDF]
, 2008 Novel liquid phase separation techniques for proteome ...
张玉奎
core
Regulation of the Liquid–liquid Phase-Separated Droplets of Biomacromolecules by Butterfly-Shaped Gold Nanomaterials [PDF]
, 2022 Liquid–liquid phase-separated (LLPS) droplets play key roles in regulating protein behaviors, such as enzyme compart-mentalization, stress response, and disease pathogenesis, in living cells.
Kentaro, Shiraki +4 more
core +1 more source