Results 51 to 60 of about 923,622 (282)

Mitigation of liquid-liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface.

PLoS ONE, 2020
Some monoclonal antibodies undergo liquid-liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics.
Tatsuji Matsuoka, Ryuki Miyauchi, Nobumi Nagaoka, Jun Hasegawa   +3 more
doaj   +1 more source

Liquid-liquid crystalline phase separation of evolving amyloid fibrils

Physical Review Research, 2023
We study the conditions necessary for the onset of liquid-liquid crystalline phase separation (LLCPS) in a system of dynamically evolving amyloid fibrils whose kinetics is controlled by nucleation, growth and fragmentation.
Paride Azzari, Raffaele Mezzenga
doaj   +1 more source

Liquid–Liquid Phase Separation and Protective Protein Aggregates in Bacteria

Molecules, 2023
Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles (MLOs) contribute to the spatiotemporal organization of various physiological processes in the cell.
Dorota Kuczyńska-Wiśnik, Karolina Stojowska-Swędrzyńska, Ewa Laskowska   +2 more
doaj   +1 more source

Liquid-liquid phase separation promotes animal desiccation tolerance [PDF]

Proceedings of the National Academy of Sciences, 2020
SignificanceRecent research has shown that intracellular proteinaceous condensates (membraneless organelles [MLOs]) are involved in various processes, ranging from Alzheimer’s disease to RNA processing, and here we demonstrate that this phenomenon governs a mechanism of anhydrobiosis.
Clinton Belott, Brett Janis, Michael A. Menze   +2 more
openaire   +2 more sources

HIx system thermodynamic model for hydrogen production by the sulfur-iodine cycle [PDF]

, 2009
The HIx ternary system (H2O – HI – I2) is the latent source of hydrogen for the Sulfur – Iodine thermo-chemical cycle. After analysis of the literature data and models, a homogeneous approach with the Peng-Robinson equation of state used for both the ...
Baudouin, Olivier, Borgard, Jean-Marc, Carles, Philippe, Floquet, Pascal, Gerbaud, Vincent, Hadj-Kali, Mohamed, Joulia, Xavier   +6 more
core   +2 more sources

Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
doaj   +1 more source

Control over phase separation and nucleation using a laser-tweezing potential [PDF]

, 2018
Control over the nucleation of new phases is highly desirable but elusive. Even though there is a long history of crystallization engineering by varying physicochemical parameters, controlling which polymorph crystallizes or whether a molecule ...
A Usman, AF Wallace, B Garetz, B Garetz, BC Knott, BC Knott, C Duffus, CD Syme, D Gebauer, D Gebauer, DK Bučar, EJG Peterman, Finlay Walton, H Masuhara, H Oana, J Hofkens, J Mosses, J Wedekind, JJ Yoreo De, JMP Gutierrez, KI Yuyama, KI Yuyama, KI Yuyama, Klaas Wynne, M Radu, MA Osborne, MR Ward, N Iefuji, N Kitamura, NF Bunkin, P Gao, P Méndez-Castro, P Tenwolde, RAL Jones, RW Bowman, T Kosa, Y Liu, Y Liu   +37 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Electrochemical Investigation of Post-Translational Modification-Modulated Biomolecular Liquid–Liquid Phase Separation [PDF]

JACS Au
Yiwei Han, Jianyang Lu, Zhenzhen Guo, Peng Miao   +3 more
doaj   +2 more sources