Results 31 to 40 of about 6,017,039 (234)
Cells, 2022 Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes.
Klizia Maccaroni +3 more
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EFhd2 Affects Tau Liquid–Liquid Phase Separation
Frontiers in Neuroscience, 2019 The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega +6 more
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Liquid–liquid phase separation in human health and diseases
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
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Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Molecules, 2023 The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present
Yanwei Wang +3 more
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Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization
Frontiers in Chemistry, 2022 Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and geologists to figure out its potential mechanism. A mounting number of studies have revealed that the classical nucleation theory is not suitable for all ...
Da Qin, Zhen He, Peng Li, Shutian Zhang
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Effects of molecular weight and temperature on liquid–liquid phase separation in particles containing organic species and inorganic salts [PDF]
Atmospheric Chemistry and Physics, 2015 Atmospheric particles containing organic species and inorganic salts may undergo liquid–liquid phase separation when the relative humidity varies between high and low values.
Y. You, A. K. Bertram
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LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
Life Science Alliance, 2023 This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
Bing Zhao +17 more
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PLoS ONE, 2020 Some monoclonal antibodies undergo liquid-liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics.
Tatsuji Matsuoka +3 more
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Liquid-liquid crystalline phase separation of evolving amyloid fibrils
Physical Review Research, 2023 We study the conditions necessary for the onset of liquid-liquid crystalline phase separation (LLCPS) in a system of dynamically evolving amyloid fibrils whose kinetics is controlled by nucleation, growth and fragmentation.
Paride Azzari, Raffaele Mezzenga
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Liquid–Liquid Phase Separation and Protective Protein Aggregates in Bacteria
Molecules, 2023 Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles (MLOs) contribute to the spatiotemporal organization of various physiological processes in the cell.
Dorota Kuczyńska-Wiśnik +2 more
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