Results 21 to 30 of about 6,322,636 (242)
When liquid-liquid phase separation meets viral infections
Frontiers in Immunology, 2022 Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown.
Wenqiang Wei +10 more
doaj +1 more source
Self-assembly coupled to liquid-liquid phase separation.
PLoS Computational Biology, 2023 Liquid condensate droplets with distinct compositions of proteins and nucleic acids are widespread in biological cells. While it is known that such droplets, or compartments, can regulate irreversible protein aggregation, their effect on reversible self ...
Michael F Hagan, Farzaneh Mohajerani
doaj +1 more source
Enhancement of DNA Droplet Formation Ability in Liquid–Liquid Phase Separation by Introduction of Artificial Nucleobase [PDF]
, 2021 Controlling liquid–liquid phase separation (LLPS) of biomolecules is a challenge for understanding its biological phenomena and developing drugs for LLPS associated diseases. We found that substitution of DNA bases with 5-nitroindoles, known as universal
Tomohiro, Kitagawa +2 more
core +2 more sources
Cells, 2022 Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes.
Klizia Maccaroni +3 more
doaj +1 more source
Designer Compartment for Artificial Metalloenzymes through Controlled Liquid-Liquid Phase Separation [PDF]
, 2021 Artificial metalloenzymes with different protein scaffolds, cofactors and functions have been prepared to expand the natural enzymatic repertoire with abiotic reactions.
Guopu, Huang +6 more
core +1 more source
Liquid - liquid flows in microchannels [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Dore, V +3 more
core +5 more sources
EFhd2 Affects Tau Liquid–Liquid Phase Separation
Frontiers in Neuroscience, 2019 The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega +6 more
doaj +1 more source
Liquid–liquid phase separation in human health and diseases
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
doaj +1 more source
Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Molecules, 2023 The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present
Yanwei Wang +3 more
doaj +1 more source
A Short Peptide Synthon for Liquid-Liquid Phase Separation [PDF]
, 2020 Liquid-liquid phase separation of disordered proteins has emerged as a ubiquitous route to membraneless compartments in living cells, and similar coacervates may have played a role when the first cells formed.
Evan, Spruijt +4 more
core +2 more sources