Results 21 to 30 of about 310,656 (114)

Effects of molecular weight and temperature on liquid–liquid phase separation in particles containing organic species and inorganic salts [PDF]

Atmospheric Chemistry and Physics, 2015
Atmospheric particles containing organic species and inorganic salts may undergo liquid–liquid phase separation when the relative humidity varies between high and low values.
Y. You, A. K. Bertram
doaj   +1 more source

Liquid–Liquid Phase Separation and Protective Protein Aggregates in Bacteria

Molecules, 2023
Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles (MLOs) contribute to the spatiotemporal organization of various physiological processes in the cell.
Dorota Kuczyńska-Wiśnik, Karolina Stojowska-Swędrzyńska, Ewa Laskowska   +2 more
doaj   +1 more source

Mitigation of liquid-liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface.

PLoS ONE, 2020
Some monoclonal antibodies undergo liquid-liquid phase separation owing to self-attractive associations involving electrostatic and other soft interactions, thereby rendering monoclonal antibodies unsuitable as therapeutics.
Tatsuji Matsuoka, Ryuki Miyauchi, Nobumi Nagaoka, Jun Hasegawa   +3 more
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Liquid-liquid crystalline phase separation of evolving amyloid fibrils

Physical Review Research, 2023
We study the conditions necessary for the onset of liquid-liquid crystalline phase separation (LLCPS) in a system of dynamically evolving amyloid fibrils whose kinetics is controlled by nucleation, growth and fragmentation.
Paride Azzari, Raffaele Mezzenga
doaj   +1 more source

LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation

Life Science Alliance, 2023
This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
Bing Zhao, Zhuoxin Li, Shaoqing Yu, Tingting Li, Wen Wang, Ran Liu, Biyu Zhang, Xiya Fang, Yezhuang Shen, Qiuying Han, Xin Xu, Kai Wang, Weili Gong, Tao Li, Ailing Li, Tao Zhou, Weihua Li, Teng Li   +17 more
doaj   +1 more source

Liquid–liquid phase separation in diseases

MedComm
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can sequester molecules to implement physiological and pathological functions.
Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang   +7 more
doaj   +1 more source

Liquid-Liquid Phase Separation in an Elastic Network

Physical Review X, 2018
Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet, surface tension drives their complete separation. Here, we show that stable droplets of uniform and tunable size can be produced through arrested phase ...
Robert W. Style, Tianqi Sai, Nicoló Fanelli, Mahdiye Ijavi, Katrina Smith-Mannschott, Qin Xu, Lawrence A. Wilen, Eric R. Dufresne   +7 more
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Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
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Liquid–liquid phase separation in hepatocellular carcinoma

Frontiers in Cell and Developmental Biology
Liquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations
Jianguo Xu, Wangwang Liu, Yihan Yao, Tuomas P. J. Knowles, Zhi-Gang Zhang, Yan-Li Zhang   +5 more
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Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science
Amyloid fibrils are rigid, elongated protein aggregates that form condensed phases in functional biological assemblies and pathological deposits. From a colloidal physics perspective, two separation pathways can lead to these condensed phases: liquid ...
Milad Radiom, Raffaele Mezzenga
doaj   +1 more source