Results 51 to 60 of about 923,946 (249)

Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
doaj   +1 more source

Phase separation phenomena during the formation of asymmetric membranes [PDF]

, 1977
The formation of membranes from two systems has been studied. In the system polyurethane-dimethylformamide-water, the mechanism for the formation of the sponge-like structure proves to be a liquid-liquid phase separation with nucleation and growth of the
Koenhen, D.M., Mulder, M.H.V., Smolders, C.A.   +2 more
core   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Membranes of semicrystalline aliphatic polyamide nylon 4,6: Formation by diffusion-induced phase separation [PDF]

, 1993
The preparation of membranes of nylon 4,6 by diffusion-induced phase separation (DIPS) using formic acid as a solvent and water as a nonsolvent was studied.
Bulte, A.M.W., Bulte, A.M.W., Folkers, Albertje, Mulder, M.H.V., Smolders, C.A., Smolders, C.A.   +5 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Separation of gas from liquid in a two-phase flow system [PDF]

, 1973
Separation system causes jets which leave two-phase nozzles to impinge on each other, so that liquid from jets tends to coalesce in center of combined jet streams while gas phase is forced to outer periphery.
Elliott, D. G., Hayes, L. G.
core   +1 more source

Hydrodynamic bubble coarsening in off-critical vapour-liquid phase separation

, 2001
Late-stage coarsening in off-critical vapour-liquid phase separation is re-examined. In the limit of bubbles of vapour distributed throughout a continuous liquid phase, it is argued that coarsening proceeds via inertial hydrodynamic bubble collapse. This
A. A. Louis, A. J. Bray, A. J. Wagner, A. J. Wagner, E. B. Dussan V, E. Velasco, G. K. Batchelor, G. Leptoukh, I. Pagonabarraga, K. E. Novik, L. D. Landau, Lord Rayleigh, M. Grant, N. G. Almarza, P. B. Warren, P. Seppecher, P. V. Coveney, Patrick B. Warren, S. I. Jury, S. W. Koch, V. M. Kendon, V. M. Kendon, W. R. Osborn, W.-J. Ma   +23 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effect of Ordering on Spinodal Decomposition of Liquid-Crystal/Polymer Mixtures

, 1998
Partially phase-separated liquid-crystal/polymer dispersions display highly fibrillar domain morphologies that are dramatically different from the typical structures found in isotropic mixtures.
A. Onuki, A.J. Liu, A.J. Liu, C. Sagui, C.V. Rajaram, D.J. Broer, D.K. Yang, D.K. Yang, G.A. Held, G.P. Crawford, H. Tanaka, I. Dierking, J.R. Dorgan, P. Mariani, P.C. Hohenberg, P.D. Olmsted, P.G. de Gennes, P.R. ten Wolde, R. Holyst, R.A.M. Hikmet, R.A.M. Hikmet, S.C. Glotzer, Y. Lansac, Y.K. Fung, Y.K. Fung, Z. Lin   +25 more
core   +1 more source