Results 61 to 70 of about 923,946 (249)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Thermodynamics, transition dynamics, and texturing in polymer-dispersed liquid crystals with mesogens exhibiting a direct isotropic/smectic-A transition [PDF]

, 2009
Experimental and modeling/simulation studies of phase equilibrium and growth morphologies of novel polymer-dispersed liquid crystal (PDLC) mixtures of PS (polystyrene) and liquid crystals that exhibit a direct isotropic/smectic-A (lamellar) mesophase ...
Abukhdeir, Nasser Mohieddin, Rey, Alejandro D., Soule, Ezequiel R.   +2 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Effect of nuclear import receptors on liquid–liquid phase separation

Biophysics and Physicobiology, 2020
Low-complexity (LC) sequences, regions that are predominantly made up of limited amino acids, are often observed in eukaryotic nuclear proteins. The role of these LC sequences has remained unclear for decades.
Takuya Yoshizawa, Hiroyoshi Matsumura
doaj   +1 more source

Nucleation at quantized vortices and the heterogeneous phase separation in supersaturated superfluid 3He-4He liquid mixtures

, 2018
Supersaturated superfluid 3He-4He liquid mixture, separating into the 3He-concentrated c-phase and 3He-diluted d-phase, represents a unique possibility for studying macroscopic quantum nucleation and quantum phase-separation kinetics in binary mixtures ...
Burmistrov, S. N., Dubovskii, L. B.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Liquid–liquid phase separation in particles containing organics mixed with ammonium sulfate, ammonium bisulfate, ammonium nitrate or sodium chloride [PDF]

Atmospheric Chemistry and Physics, 2013
As the relative humidity varies from high to low values in the atmosphere, particles containing organic species and inorganic salts may undergo liquid–liquid phase separation.
Y. You, L. Renbaum-Wolff, A. K. Bertram
doaj   +1 more source

Criticality in strongly correlated fluids

, 2001
In this brief review I will discuss criticality in strongly correlated fluids. Unlike simple fluids, molecules of which interact through short ranged isotropic potential, particles of strongly correlated fluids usually interact through long ranged forces
Bjerrum N, Brush S G, Clausius R, de Gennes P G, de Laplace P S, Debye P W, Fisher M E, Gibbs J W, Maxwell J C, Newton I 1687, Newton I 1730, Panagiotopoulos A Z, Pitzer K S, Rushbrooke G S, Tavares J M, Tavares J M, van der Waals J D, Wertheim M S, Wilson K G, Yan Levin   +19 more
core   +1 more source

Toward a complete description of nucleation and growth in liquid-liquid phase separation [PDF]

, 2004
The phase separation mechanism of a binary liquid mixture off-critically quenched in its miscibility gap is nucleation and growth, its homogeneous phase reaching a metastable equilibrium state.
Bert, Jacques, Colombani, Jean
core   +3 more sources