Results 111 to 120 of about 143,872 (300)

Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation

open access: yesNature Communications
Biomolecular condensates play wide-ranging roles in cellular compartmentalization and biological processes. However, their transition from a functional liquid-like phase into a solid-like state—usually termed as condensate ageing—represents a hallmark ...
Ignacio Sanchez-Burgos   +5 more
doaj   +1 more source

Biomolecular condensates modulate membrane lipid packing and hydration

open access: yesNature Communications, 2023
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in cell biology, playing an important role in a diverse range of processes across different organisms.
Agustín Mangiarotti   +5 more
doaj   +1 more source

Resonant scattering of positronium as a quasifree electron [PDF]

open access: yes, 2017
In order to clarify the physics underlying the observations of the electronlike behavior of positronium (Ps) and its resonant scattering from CO2, we have measured the Ps+N2 total cross section and found it also to exhibit significant structure. Analysis
B. H. Bransden   +5 more
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

open access: yesAdvanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge   +14 more
wiley   +1 more source

In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability. [PDF]

open access: yes
Recently, the pyrazole-containing synthetic cannabinoid N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) has been identified as a 'research chemical' both in powdered form and as ...
Angerer, V   +6 more
core   +1 more source

Wet Chemical Method for Determining Levels of Ammonia in Syngas from a Biomass Gasifier [PDF]

open access: yes, 2005
A wet chemical sampling method using acidic absorbing solutions was used to determine levels of ammonia (NH3) in syngas from a biomass gasifier. Before syngas is bubbled into the absorbing solutions, a quartz thimble filter is used to filter ash from the
Brown, Robert   +2 more
core   +3 more sources

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

open access: yesAdvanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang   +8 more
wiley   +1 more source

Generation of Motion of Drops with Interfacial Contact

open access: yes, 2015
A liquid drop moves on a solid surface if it is subjected to a gradient of wettability or temperature. However, the pinning defects on the surface manifested in terms of a wetting hysteresis, or first-order nonlinear friction, limit the motion in the ...
Chakrabarti, Aditi   +2 more
core   +3 more sources

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

open access: yes, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark   +11 more
core   +2 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao   +11 more
wiley   +1 more source

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