Results 121 to 130 of about 116,047 (273)

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +2 more sources

Multifunctional Matrix‐Activated Electrodes Enabling Efficient Proton Transport and Durable Low‐Pt Operation for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Energy Materials, EarlyView.
This work introduces a CeHP‐enabled multifunctional matrix‐activated electrode (MME) for high‐temperature PEM fuel cells, forming an electrochemically and mechanically functional matrix within the catalyst layer. The design increases peak power density by 38% and reduces voltage decay by 62% at 240 °C, while using only 40% of the Pt loading of a ...
Gyeongseok Gwak, Sunjin Park, Joonbyum Kim, Hena Lee, Jihyeon Ok, Chae Young Lee, JunHwa Kwon, Jong Geun Seong, Sung Pil Yoon, Suk‐Woo Nam, Hansung Kim, Katie Heeyum Lim, So Young Lee   +12 more
wiley   +1 more source

Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization

Nature Communications
Phase-separated biomolecular condensates are functional elements in cells, contribute to protocell formation in prebiotic systems, and represent a distinct class of soft matter.
Vahid Sheikhhassani, Faith H. K. Wong, Daniel Bonn, Jeremy D. Schmit, Alireza Mashaghi   +4 more
doaj   +1 more source

Overcoming the Nyquist Limit in Molecular Hyperspectral Imaging by Reinforcement Learning

Advanced Intelligent Discovery, EarlyView.
Explorative spectral acquisition guide automatically selects informative spectral bands to optimize downstream tasks, outperforming full‐spectrum acquisition. The selected hyperspectral data are used for tasks such as unmixing and segmentation. BandOptiNet encodes selection states and outputs optimal bands to guide spectral acquisition. Recent advances
Xiaobin Tang, Yongqing Zhang, Xinyu Deng, Hyeon Jeong Lee, Delong Zhang   +4 more
wiley   +1 more source

Artificial Intelligence for Advanced Functional Materials: Progress and Emerging Frontiers

Advanced Intelligent Systems, EarlyView.
Artificial intelligence is transforming the discovery of functional materials by linking synthesis, characterization, simulation, and design in unified workflows. Advances in machine learning, autonomous experimentation, and foundation models are accelerating innovation across energy, electronics, and biomedicine, while revealing new frontiers for ...
Cristiano Malica, Kostya S. Novoselov, Seongmin Kim, Yousung Jung, Silvana Botti, Miguel A. L. Marques, Tigany Zarrouk, Miguel A. Caro, Sanggyu Chong, Michele Ceriotti, Marivi Fernandez‐Serra, Sara Navarro‐Rodriguez, Aakash Ashok Naik, Janine George, Ömer Hasan Omar, Victor Trinquet, Gian‐Marco Rignanese, Andrey Ustyuzhanin, Sonia Conesa‐Boj, Juan Rojo, Minh‐Tuan Dau, Simon M.‐M. Dubois, Jean‐Christophe Charlier, Jose H. Garcia, Romain Gautier, Rachid Laref, Junfeng Qiao, Giovanni Pizzi, Nicola Marzari, Camilla Coletti, Antonio Rossi, Jan‐Lucas Uslu, Chiara Zanardi, Vincenzo Palermo, Wide Hogenhout, Natalia Konchakova, Peter Klein, Tejs Vegge, Stephan Roche   +38 more
wiley   +1 more source

Dual effect of α-synuclein disease variants on condensate formation

Nature Communications
α-synuclein is a pre-synaptic protein implicated in synucleinopathies including Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites ...
Aswathy Chandran, Aishwarya Agarwal, Tianhao Wang, Leslie Amaral, Shiyue Chen, Susana R. Chaves, Tiago F. Outeiro, Janin Lautenschläger   +7 more
doaj   +1 more source

Accelerating Materials Discovery: A Review of Machine Learning in X‐Ray Absorption Spectroscopy

Advanced Intelligent Systems, EarlyView.
This review systematically details how machine learning transforms X‐ray absorption spectroscopy (XAS) analysis. It covers advanced deep learning architectures for structure‐spectra mapping and inverse tasks, while discussing key challenges like the simulation‐to‐reality gap.
Melaku Lake Tegegne, Haodong Yao, Liyuan Wu, Yihe Pang, Fazhi Qi, Lina Zhao   +5 more
wiley   +1 more source

Optical Control of the Glucocorticoid Receptor Activity With a Photoswitchable Agonist

Angewandte Chemie, EarlyView.
A photoswitchable glucocorticoid receptor agonist enables optical control of receptor activity, achieving picomolar potency and partial agonism that preferentially maintains anti‐inflammatory signaling over canonical transcriptional activation. ABSTRACT Glucocorticoids (GCs) are widely prescribed anti‐inflammatory agents whose clinical utility is ...
Zoe Sessions, Chloé Van Leene, Dorien Clarisse, George Keen, Agnė Šveistytė, Dinahlee Saturnino Guarino, Robert H. Mach, Karolien De Bosscher, Dirk Trauner   +8 more
wiley   +2 more sources

Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

Molecular Oncology
Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex.
Erich J. Sohn, David S. Libich
doaj   +1 more source

Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates

Nature Communications
Aggregation of amyloidogenic proteins is linked to age-related diseases. The presence of interfaces can affect their aggregation mechanism, often speeding up aggregation.
Brent S. Visser, Merlijn H. I. van Haren, Wojciech P. Lipiński, Kirsten A. van Leijenhorst-Groener, Mireille M.A.E. Claessens, Marcos V. A. Queirós, Carlos H. I. Ramos, Jorine Eeftens, Evan Spruijt   +8 more
doaj   +1 more source