Results 121 to 130 of about 143,872 (300)

Spectrin condensates provide a nidus for assembling the axonal membrane-associated periodic skeleton

iScience
Summary: In axons, α/β-spectrins, adducin, and actin filaments assemble into a lattice underneath the plasma membrane, but the mechanistic events leading to this membrane-associated periodic skeleton (MPS) are unclear.
Nicholas P. Boyer, Rohan Sharma, Theresa Wiesner, Christopher Parperis, Antoine Delamare, Florence Pelletier, Nicolas Jullien, Anshul M. Bhatt, Leonardo A. Parra-Rivas, Patrick J. Kearney, Farbod Shavarebi, Christophe Leterrier, Subhojit Roy   +12 more
doaj   +1 more source

Single-molecule stochastic resonance

, 2012
Stochastic resonance (SR) is a well known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic noise.
de Lorenzo, S., Hayashi, K., Huguet, J. M., Manosas, M., Ritort, F.   +4 more
core   +2 more sources

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Biomolecular condensates in neurodegeneration and cancer [PDF]

Traffic, 2019
Abstract The intracellular environment is partitioned into functionally distinct compartments containing specific sets of molecules and reactions. Biomolecular condensates, also referred to as membrane‐less organelles, are diverse and abundant cellular compartments that lack membranous enclosures.
Stephanie Spannl, Maria Tereshchenko, Giovanni J. Mastromarco, Sean J. Ihn, Hyun O. Lee   +4 more
openaire   +2 more sources

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction

Cell Insight
Biomolecular condensates have emerged as fundamental organizers of cellular biochemistry. Increasing evidence indicates that cellular condensates exhibit a broad spectrum of material properties—including viscoelastic, soft glass-like, gel-like, and quasi-
Jingxuan Luo, Zhehao Li, Ziyin Shen, Xiaoyu Zhai, Jiayue Chen, Hanchun Wang, Xueping Zhao, Jing He, Mingrui Ding   +8 more
doaj   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Reconfiguration of Multiphase Coacervate Droplets Into Self‐Regulated Nested Artificial Cells

Angewandte Chemie, EarlyView.
Living cells advance functionality through spatiotemporal sub‐compartmentalization and internal organization. Herein, we develop a self‐regulated artificial cell by transforming a membrane‐less multiphase coacervate droplet (MCD) into a membranized, structurally reinforced nested coacervate vesicle (NCV).
Zhuping Yin, Rui Sun, Jingxin Shao, Jan C. M. van Hest, Stephen Mann   +4 more
wiley   +2 more sources

Protein modifications and ionic strength show the difference between protein-mediated and solvent-mediated regulation of biomolecular condensation

Frontiers in Nanotechnology
Biomolecular condensation is an important mechanism of cellular compartmentalization without membranes. Formation of liquid-like condensates of biomolecules involves protein-protein interactions working in tandem with protein-water interactions.
Artur Czajkowski, Artur Czajkowski, Abhirami Udayabanu, Abhirami Udayabanu, Manthan Raj, Manthan Raj, Likhitha Ch. P. Pulibandla, Likhitha Ch. P. Pulibandla, Marija Tursunović, Marcus Jahnel, Marcus Jahnel, Ellen M. Adams, Ellen M. Adams   +12 more
doaj   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source