Results 21 to 30 of about 116,047 (273)
Molecular structure in biomolecular condensates [PDF]
Current Opinion in Structural Biology, 2020 Evidence accumulated over the past decade provides support for liquid-liquid phase separation as the mechanism underlying the formation of biomolecular condensates, which include not only membraneless organelles such as nucleoli and RNA granules, but additional assemblies involved in transcription, translation and signaling. Understanding the molecular
Ivan Peran, Tanja Mittag
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Biomolecular condensate phase diagrams with a combinatorial microdroplet platform. [PDF]
, 2023 The assembly of biomolecules into condensates is a fundamental process underlying the organisation of the intracellular space and the regulation of many cellular functions.
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Protein conformation and biomolecular condensates
Current Research in Structural Biology, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts. An avalanche of studies highlighted the central role of biomolecular condensates in membraneless subcellular ...
Diego S. Vazquez +3 more
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Higher-order organization of biomolecular condensates
Open Biology, 2021 A guiding principle of biology is that biochemical reactions must be organized in space and time. One way this spatio-temporal organization is achieved is through liquid–liquid phase separation (LLPS), which generates biomolecular condensates.
Charlotte M. Fare +3 more
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, 2022 Data for figures in manuscript and supporting information for ' High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform'. Data for protein phase diagrams generation and related supporting information as acquired
Jordina Guillén-Boixet (9953816) +14 more
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Poly(ADP-Ribose): A Dynamic Trigger for Biomolecular Condensate Formation [PDF]
Trends in Cell Biology, 2020 Anthony Leung
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Biomolecular condensates in neurodegeneration and cancer [PDF]
Traffic, 2019 Abstract The intracellular environment is partitioned into functionally distinct compartments containing specific sets of molecules and reactions. Biomolecular condensates, also referred to as membrane‐less organelles, are diverse and abundant cellular compartments that lack membranous enclosures.
Stephanie Spannl +4 more
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Engineering synthetic biomolecular condensates
Nature Reviews Bioengineering, 2023 The concept of phase-separation-mediated formation of biomolecular condensates provides a new framework to understand cellular organization and cooperativity-dependent cellular functions. With growing understanding of how biological systems drive phase separation and how cellular functions are encoded by biomolecular condensates, opportunities have ...
Yifan Dai +2 more
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Topological Considerations in Biomolecular Condensation
Biomolecules, 2023 Biomolecular condensation and phase separation are increasingly understood to play crucial roles in cellular compartmentalization and spatiotemporal regulation of cell machinery implicated in function and pathology. A key aspect of current research is to gain insight into the underlying physical mechanisms of these processes.
Debapriya Das, Ashok A. Deniz
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Principles and functions of condensate modifying drugs
Frontiers in Molecular Biosciences, 2022 Biomolecular condensates are compartmentalized communities of biomolecules, which unlike traditional organelles, are not enclosed by membranes. Condensates play roles in diverse cellular processes, are dysfunctional in many disease states, and are often ...
Avinash Patel +5 more
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