Results 11 to 20 of about 116,047 (273)
Protein Condensate Atlas from predictive models of heteromolecular condensate composition [PDF]
Nature CommunicationsBiomolecular condensates help cells organise their content in space and time. Cells harbour a variety of condensate types with diverse composition and many are likely yet to be discovered.
Kadi L. Saar +7 more
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Topography-driven movement of biomolecular condensates.
PLoS ONEBiomolecular condensates are assemblies of proteins or nucleic acids that exhibit liquid-like properties and organize intracellular biochemical reactions within many cells.
Matthias Pöllmann, Katja Zieske
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Biomolecular condensate phase diagrams with a combinatorial microdroplet platform. [PDF]
Nat Commun, 2022 The assembly of biomolecules into condensates is a fundamental process underlying the organisation of the intracellular space and the regulation of many cellular functions.
Arter WE +16 more
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Systematic discovery of biomolecular condensate-specific protein phosphorylation. [PDF]
Nat Chem Biol, 2022 Reversible protein phosphorylation is an important mechanism for regulating (dis)assembly of biomolecular condensates. However, condensate-specific phosphosites remain largely unknown, thereby limiting our understanding of the underlying mechanisms. Here,
Sridharan S +9 more
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Focus on biomolecular condensates [PDF]
The Plant Cell, 2023 descripción no proporcionada por ...
Emilio Gutierrez-Beltran +2 more
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Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry. [PDF]
Chem Rev, 2022 International audienceMotions in biomolecules are critical for biochemical reactions. In cells, many biochemical reactions are executed inside of biomolecular condensates formed by ultradynamic intrinsically disordered proteins.
Abyzov A, Blackledge M, Zweckstetter M.
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Converging frontiers in biomolecular condensate and synthetic cell research. [PDF]
NPJ Biomed InnovBiomolecular condensate and artificial cell research, though distinct in origin, share a focus on studying and mimicking (sub)cellular compartments. Identifying converging frontiers offers opportunities to advance both fields.
Verwiel MAM, Erkamp NA, Hest JCMV.
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Biomolecular condensates in cancer biology [PDF]
Cancer Science, 2021 AbstractUnderstanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis ...
Hiroshi I. Suzuki, Koh Onimaru
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Extreme dynamics in a biomolecular condensate. [PDF]
Nature, 2023 Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular condensates$^{1-4}$. The functions of condensates span many length scales: they modulate interactions and chemical reactions at the molecular scale$^{5}$, organize biochemical processes at the mesoscale$^{6}$ and compartmentalize cells$^{4}$.
Galvanetto N +7 more
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Biomolecular condensation involving the cytoskeleton
Brain Research Bulletin, 2023 Biomolecular condensation of proteins contributes to the organization of the cytoplasm and nucleoplasm. A number of condensation processes appear to be directly involved in regulating the structure, function and dynamics of the cytoskeleton. Liquid-liquid phase separation of cytoskeleton proteins, together with polymerization modulators, promotes ...
Satabdee Mohapatra, Susanne Wegmann
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