Results 171 to 180 of about 98,340 (384)
Chemistry &Biodiversity, EarlyView.Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim +8 more
wiley +1 more source
Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides
ChemBioChem, EarlyView.Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine +13 more
wiley +1 more source
Strange Bedfellows: Native American Tribes, Big Pharma, and the Legitimacy of Their Alliance [PDF]
, 2006 Lost in the cacophony surrounding the debate about high drug prices is the fundamental principle that pharmaceutical innovation will not occur without the prospect of outsized returns enabled through market exclusivity.
Chenine, Moustafa +2 more
core +1 more source
ChemistryEurope, EarlyView.This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink +3 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia +8 more
wiley +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2018 The present article submits the results of work on the isolation and study of biological properties of bacteriophages, active against Klebsiella, Echerichia, Proteus, Pseudomonas, Staphylococcus.
E. N. Siatchikhina +4 more
doaj