Results 221 to 230 of about 101,810 (380)

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Research and development financing models for new biopharmaceuticals in the United States. [PDF]

Health Aff Sch
Kang SY, Lee B, Gupta R, Ballreich J, Anderson G.   +4 more
europepmc   +1 more source

Color Flow Imaging Microscopy Improves Identification of Stress Sources of Protein Aggregates in Biopharmaceuticals [PDF]

Michaela Cohrs, Shiwoo Koak, Yejin Lee, Yu Sub Sung, Wesley De Neve, Hristo L. Svilenov, Utku Özbulak   +6 more
openalex   +1 more source

Using generalized quantitative structure–property relationship (QSPR) models to predict host cell protein retention in ion‐exchange chromatography

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Selecting an optimal chromatography resin during biopharmaceutical downstream process development is a great challenge. This is especially the case for recombinant subunit vaccines, where product properties vary greatly and recovery often involves cell lysis, which yields a complex mixture of different host cell materials. Host cell
Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke E Klijn, Marcel Ottens   +4 more
wiley   +1 more source

Physics-based surface patch analysis for prediction of hydrophobic contribution to viscosity of mAbs. [PDF]

MAbs
Knez B, Ravnik M, Zidar M.
europepmc   +1 more source

Sample Management and Factors to be Considered for Biopharmaceutical Characterisation

Amisha Mahesh Bhopatrao, Dipesh Adesh Gamare   +1 more
openalex   +1 more source

Cysteine Reactivity Profiling Illuminates Monoclonal Antibody Disulfide Bond Reduction Mechanisms in Biopharmaceutical Process Intermediates [PDF]

Taku Tsukidate, Zhenshu Wang, Andrew Hsieh, Patricia Rose, Xuanwen Li   +4 more
openalex   +1 more source

Optimizing rapeseed protein purification: a continuous chromatographic approach for napin and cruciferin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Napin and cruciferin, the predominant storage proteins in Brassica napus (rapeseed), exhibit favorable techno‐functional properties such as emulsification and gel formation, positioning them as promising candidates for the encapsulation and delivery of bioactive compounds. Their classification as GRAS (Generally Recognized As Safe),
Jonas Arnecke, Jessica Gillmann, Tim Börner, Mathias Hafner, Christian Frech   +4 more
wiley   +1 more source

Models attempting to quantify the relationship between drug development and financial return are missing a key element: the effect on post-approval research. [PDF]

Health Aff Sch
Crippen D, Axelsen K.
europepmc   +1 more source

Bio-production CMO & CRO Market Size, Trends, and Forecast 2024-2030 | Global Biopharmaceutical Outsourcing

Next Move Strategy Consulting
openalex   +1 more source