Results 71 to 80 of about 70,680 (286)
Advanced Science, EarlyView.A dual‐network architecture combining a thermally reinforced hydrogen‐bonding matrix with an amine‐anhydride covalent framework was constructed in Tröger's Base (TB)‐functionalized polybenzimidazoles. This design yielded the TBAm‐PBI‐TB membrane with high acid uptake (469.5%), anhydrous conductivity (264.7 mS cm−1), and robust stability.
Junming Dai +6 more
wiley +1 more source
The Future of Generic Biologics: Should the United States “Follow-On” the European Pathway? [PDF]
, 2008 The United States is embarking on a biotechnology drug revolution. In the last few decades, biotech drugs have saved millions of lives, and the market for these miracle cures continues to grow at an astronomical rate.
Kaldre, Ingrid
core +1 more source
Advanced Science, EarlyView.Fabrication‐induced variability remains a fundamental limitation in the scalable design of soft biomaterials. In this work, a stochastic machine learning approach based on Gaussian processes modeling is employed to establish quantitative links between biofabrication parameters, material properties, and their intrinsic variability.
Maria Alexaki +8 more
wiley +1 more source
mAbsThe multi-attribute method (MAM) by liquid chromatography-mass spectrometry peptide mapping has the potential to replace multiple conventional HPLC- and capillary electrophoresis-based purity/impurity assays for release and stability testing of protein ...
Thomas Pohl +14 more
doaj +1 more source
Multiple Elements in Single Words [PDF]
, 2019 What\u27s the shortest word from which the names of 2 chemical elements can be spelled ...
Francis, Darryl
core +1 more source
Advanced Science, EarlyView.We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao +23 more
wiley +1 more source
Technological Discontinuities and the Comparative Strategic Value of New Capabilites: Evidence from the Comparison of Small- and Large-Molecule Targeted Anti-Cancer Drug Discovery [PDF]
Traditional creative destruction theories distinguish disruptions as competence-destroying or competence-enhancing to incumbents’ capabilities, with the former case resulting in incumbents’ loss of competitive advantage in in-house R&D performance (even ...
M. Lourdes Sosa
core
Biopharmaceuticals: Priority Sector Report
, 2019 The Biopharmaceuticals emerging industry is the result of an evolution of the traditional pharmaceutical industry that emerged in the late 1800s, mainly based on chemical production. The industry has incorporated the more recent emergence of biotechnology developed on living cells and molecules, stemming from key innovations in the 1970s and 1980s ...
openaire +2 more sources
AIChE Journal, EarlyView.Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto +6 more
wiley +1 more source
Editorial: Separation Processes in Pharmaceutical Manufacturing
Frontiers in Chemical Engineering, 2022 Cristina Chuck-Hernández +4 more
doaj +1 more source