Results 111 to 120 of about 39,175 (290)
Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule
Biopharmaceutics &Drug Disposition, EarlyView.This investigation discusses two clinical studies. One investigated the effect of fatty meals (≥ 25% fat) on vatiquinone PK exposures, and the other one characterized vatiquinone PK profiles when administered on a TID dosing regimen corresponding to mealtimes. The data support the recommendation of administering vatiquinone with fatty meals (≥ 25% fat)
Lucy Lee +6 more
wiley +1 more source
Microbial Cell FactoriesBackground Aminoglycoside antibiotics continue to play an indispensable role in clinical antibacterial agents. However, the protection and deprotection procedures in the chemical pathways of semi-synthetic antibiotics are long, atom- and step-inefficient,
Hang Zhai +11 more
doaj +1 more source
Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells
Biotechnology and Bioengineering, EarlyView.In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos +9 more
wiley +1 more source
BMEMat, EarlyView.Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu +9 more
wiley +1 more source
Use of vaccinia virus to express biopharmaceutical products. [PDF]
, 1987 Dennis E. Hruby, Gary Thomas
openalex +1 more source
BMEMat, EarlyView.BSO/CAT@Liposomes‐Hemoporfin nanoparticles could significantly enhance the ROS levels in cells in vitro and tumor model in vivo, which is attributed to the increasement of Hemoporfin in the tumor, depletion of GSH, and enhancement of local oxygen concentration.
Yawen Chen +7 more
wiley +1 more source
Biopharmaceutics of rectal administration of drugs in man [PDF]
, 1980 Frits Moolenaar
openalex +1 more source
Editorial: From microbial immunology to microbial therapeutics via targeted delivery technology
Frontiers in Immunology, 2022 Matteo Puccetti +3 more
doaj +1 more source