Results 111 to 120 of about 17,488 (290)

Improving activity of GenB3 and GenB4 in gentamicin dideoxygenation biosynthesis by semi-rational engineering

Microbial Cell Factories
Background Aminoglycoside antibiotics continue to play an indispensable role in clinical antibacterial agents. However, the protection and deprotection procedures in the chemical pathways of semi-synthetic antibiotics are long, atom- and step-inefficient,
Hang Zhai, Lihua Yang, Qi Ye, Zhijun Kong, Jiye Pei, Yuan Ji, Botong Liu, Xiaotang Chen, Tingting Tian, Xianpu Ni, Huanzhang Xia, Shumin Zhang   +11 more
doaj   +1 more source

A History of Biopharmaceutics in the Food and Drug Administration 1968–1993 [PDF]

, 2009
Jerome P. Skelly
openalex   +1 more source

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

Biotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse, Fabian Schmitz, Janina Kilian, Jonas Austerjost, Lucas‐Nik Reger, Markus Kampmann   +5 more
wiley   +1 more source

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji, Kosuke Kusamori, Chihiro Tanaka, Hideki Sakai, Shoko Itakura, Makiya Nishikawa   +5 more
wiley   +1 more source

Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses with OLS and hybrid modeling [PDF]

, 2023
Verena Nold, Lisa Junghans, Benjamin Bayer, Lorenzo Bisgen, Mark Duerkop, Raphael Drerup, Beate Presser, Thomas Schwab, Erich Bluhmki, Stefan Wieschalka, Bettina L. Knapp   +10 more
openalex   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy

Discover Oncology
Tumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of malignant cells. Complex transitions involving dormant tumor cells between quiescent and proliferative states pose challenges for ...
Yuan Wang, Linlin Wang, Yaojun Wei, Chuang Wei, Haohang Yang, Qiurui Chen, Rongxin Zhang, Han Shen   +7 more
doaj   +1 more source

Announcing the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology [PDF]

, 2009
Juergen Siepmann
openalex   +1 more source

Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

Editorial: From microbial immunology to microbial therapeutics via targeted delivery technology

Frontiers in Immunology, 2022
Matteo Puccetti, César Viseras Iborra, Luigina Romani, Maurizio Ricci   +3 more
doaj   +1 more source