Results 141 to 150 of about 39,175 (290)

Population Pharmacokinetic and Exposure‐Response Analysis of the Cognitive Effects of TAK‐071 in Participants With Parkinson Disease and Cognitive Impairment

Clinical Pharmacology in Drug Development, EarlyView.
Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan, Niraj M. Shanbhag, Brian T. Harel, Arthur Simen, Wei Yin   +8 more
wiley   +1 more source

Riposte: FDA response to 'Yin, yang and the biopharmaceutical industry'

, 1969
Amy S. Rosenberg, Karen D. Weiss, Michael Lanthier, Roger Eastep, William Egan, Jesse L. Goodman, Janet Woodcock   +6 more
openalex   +2 more sources

Biopharmaceutical sector performance, 4th quarter 1999 [PDF]

, 2000

openalex   +1 more source

Safety, Tolerability, and Pharmacokinetics of the Long‐Acting SARS‐CoV‐2–Neutralizing Monoclonal Antibody Combination AZD7442 (Tixagevimab/Cilgavimab) in Healthy Chinese Adults

Clinical Pharmacology in Drug Development, EarlyView.
Abstract AZD7442, a combination of extended half‐life monoclonal antibodies tixagevimab and cilgavimab, was shown to neutralize previously circulating SARS‐CoV‐2 variants. This study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 in healthy Chinese adults. In this randomized, placebo‐controlled, Phase 1 study, AZD7442
Nanyang Li, Jing Zhang, Wenhong Zhang, Zhongyuan Xu, Xiangcao Yao, Anqi He, Shuyuan Liu, Xiaoyun Ge, Jinxi Liu, Yunfei Li, Cecil Chi‐Keung Chen, Huixia Zhang   +11 more
wiley   +1 more source

Biopharmaceutical study of the hepato-biliary transport of drugs. IV. Development of the method to investigate the process of the active secretion of drugs from the hepatocytes into the bile canaliculi and its application to the biliary excretion of organic anions in rat.

, 1976
Kanji Takada, Yuji Tokunaga, Shozo Muranishi   +2 more
openalex   +2 more sources

The biopharmaceutical aspects of nasal mucoadhesive drug delivery [PDF]

, 2001
Michael Ikechukwu Ugwoke, Norbert Verbeke, Renaat Kinget   +2 more
openalex   +1 more source

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells [PDF]

, 2003
The main aim of this work was to develop novel targeted sterically stabilised pH-sensitive liposomes tailored to promote efficient intracellular delivery of therapeutic molecules into human T-leukaemia cells.
Fonseca, Cristina, Moreira, João N., Ciudad, Carlos J., Pedroso de Lima, Maria C., Simões, Sérgio   +4 more
core   +2 more sources

Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In total, 272 participants were randomized 3:1 to a single intravenous dose of 600 mg AZD7442 or placebo and
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Haiyue Zhang, Yunfei Li, Cecil Chi‐Keung Chen, Oleg Stepanov, Weifeng Tang, Wenhong Zhang   +10 more
wiley   +1 more source

"Biopharmaceutical studies on the parenteral preparations". VIII. Effect of some ionic and nonionic surfactants on the intramuscular absorption of isonicothinamide.

, 1975
Hiroshi Kobayashi, TSOCHIN PENG, Akira Kagayama, Katsuhiko Okumura, Shozo Muranishi, Hitoshi Sezaki   +5 more
openalex   +2 more sources

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source