Results 231 to 240 of about 15,283 (290)

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC–MS/MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Non‐reduced trypsin digestion of therapeutic antibodies can generate large disulfide‐linked peptide complexes that exhibit poor chromatographic and mass spectrometric performance. This limits the confident characterization of posttranslational modifications (PTMs) in specific antibody regions, such as the heavy‐chain constant region ...
Nanna Sofie Eskesen, Yann Leblanc, Justine Lempereur, Martin Ørgaard, Elizabeta Madzharova, Trine M. Sloth, Simon Krabbe, Alexandra K. Rebak, Magali André, Pernille F. Jensen, Dan B. Kristensen   +10 more
wiley   +1 more source

Classification system proposed to guide the design, development, regulatory approval, and scaling of long acting, small- and macro-molecule parenteral products (CS-BLAP). [PDF]

J Pharm Sci
Perazzolo S, Shen DD, Ho RJY.
europepmc   +1 more source

Virtual Bioequivalence Assessment and Dissolution Safe Space Exploration for Fixed-Dose Metformin-Glyburide Tablet Using Physiologically Based Biopharmaceutics Modeling. [PDF]

Pharmaceutics
Zhao C, Shen C, Xiao Y, Wang L.
europepmc   +1 more source

First reported survival of anthrax meningoencephalitis in a low-incidence region: successful management with mNGS-guided combination therapy. [PDF]

Front Cell Infect Microbiol
Geng Q, Wang Y, Fan Y, Liu N, Zhao X.
europepmc   +1 more source

Correction: Meta-analysis of the efficiency and safety of neoadjuvant therapy with immune checkpoint inhibitors in resectable hepatocellular carcinoma. [PDF]

Front Med (Lausanne)
Frontiers Production Office.
europepmc   +1 more source

Spatial Segregation Within Dissolving Microneedle Patches Overcomes Antigenic Interference and Enables Potent Bivalent Influenza-RSV Vaccination in Mice. [PDF]

Vaccines (Basel)
Fan F, Wu Y, Lin H, Zhang X, Wang L, He Y, Zhang S, Zhang M, Zhao G, Xiang R, Kang Y, Chen M, Li Z, Guo YB, Zhou H, Zhao C, Wang MC, Gu JY, Wang B, Gao XM.   +19 more
europepmc   +1 more source

The effect of varying water volumes on in vivo dissolution and gastric emptying of highly soluble caffeine and lesser soluble theobromine containing capsules. [PDF]

Int J Pharm X
Großmann L, Cyrus J, Senekowitsch S, Wildgrube T, Kromrey ML, Weitschies W, Schick P, Grimm M.   +7 more
europepmc   +1 more source

The need for dried plasma—Still a national issue: Where are we and recommendations

Transfusion, EarlyView.
Anthony E. Pusateri, Shibani Pati, Toby A. Silverman, Roman Dudaryk, Joseph F. Rappold, Lisa Buckley, Andrew P. Cap, Jose A. Cancelas, Laurence M. Corash, G. Michael Fitzpatrick, Michael Ganio, Adam Gerber, Richard Gonzales, Jennifer M. Gurney, Ernest E. Moore, Hunter B. Moore, Vijayan Nair, Michael Policastro, Travis M. Polk, Jeffrey W. Shupp, Jason L. Sperry, Ralph R. Vassallo, Therese A. West, John B. Holcomb, Lester Martinez‐Lopez   +24 more
wiley   +1 more source

Comments on Statistical Analysis of “Comparative Efficacy and Safety of Ilunocitinib and Oclacitinib for the Control of Pruritus and Associated Skin Lesions in Dogs With Atopic Dermatitis”

Veterinary Dermatology, EarlyView.
Michal Hakala, Eva Zschiesche, Petr Hala, Inka Kuhlmann   +3 more
wiley   +1 more source

Introduction. Biopharmaceutics and Pharmacokinetics

, 2018
Biopharmaceutics and pharmacokinetics are pharmaceutical disciplines useful to improve the outcome of drug therapies, assist drug product development, and establish pharmacokinetics-pharmacodynamics models and in vitro-in vivo correlations. Here, we introduce some essential lexicon that will be used throughout this volume and discuss the relationship ...
Talevi, Alan, Quiroga, Pablo A. M.
openaire   +3 more sources