Results 61 to 70 of about 690,369 (235)

Positioning Membrane Proteins by Novel Protein Engineering and Biophysical Approaches [PDF]

Journal of Molecular Biology, 2005
Membrane proteins are unique, in that they can function properly only when they are bound to cellular membranes in a distinct manner. Therefore, positioning of membrane proteins with respect to the membrane is required in addition to the three-dimensional structures in order to understand their detailed molecular mechanisms.
Tatulian, Suren A., Qin, Shan, Pande, Abhay H., He, Xiaomei   +3 more
openaire   +4 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Physiology, Biophysics, and Biomedical Engineering. [PDF]

Medical Physics, 2014
Physiology, Biophysics, and Biomedical Engineering. Wood A. W., CRC Press, Taylor & Francis Group, Boca Raton, FL, 2012, 782 pp. (hardcover). Price: $99.95.
openaire   +1 more source

SENTINEL FOR APPLICATIONS IN AGRICULTURE [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
The European Union and the European Space Agency (EU/ESA) have promoted since 1998 (Baveno Manifesto*) the GMES Programme (Global Monitoring for Environment and Security), nowadays called Copernicus (www.copernicus.eu). In the agriculture domain, the use
M. A. Gomarasca, A. Tornato, D. Spizzichino, E. Valentini, A. Taramelli, A. Taramelli, G. Satalino, M. Vincini, M. Boschetti, R. Colombo, L. Rossi, E. Borgogno Mondino, L. Perotti, W. Alberto, F. Villa   +14 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Biophysical modelling as a tool for advancing plant science and engineering

Frontiers in Plant Science
Plant growth, development, and physiology are governed by complex processes operating across scales spanning from molecular, cellular, tissue, and whole organism. Experimental studies have uncovered key mechanisms underlying hormone signalling, gene regulation, metabolism, and environmental responses.
Deb, Debanik, Chakrabortty, Bandan
openaire   +2 more sources

Advancing wetland mapping in Argentina: A probabilistic approach integrating remote sensing, machine learning, and cloud computing towards sustainable ecosystem monitoring

Watershed Ecology and the Environment
Wetlands, covering 7 % of Earth’s surface, are crucial for providing ecosystem services and regulating climate change. Despite their importance, global fluctuations in wetland distribution highlight the need for accurate and comprehensive mapping to ...
María F. Navarro Rau, Noelia C. Calamari, Carlos S. Navarro, Andrea Enriquez, María J. Mosciaro, Griselda Saucedo, Raul Barrios, Matías Curcio, Victorio Dieta, Guillermo García Martínez, María del R. Iturralde Elortegui, Nicole J. Michard, Paula Paredes, Fernando Umaña, Silvina Alday, Alejandro Pezzola, Claudia Vidal, Cristina Winschel, Silvia Albarracin Franco, Santiago Behr, Francisco A. Cianfagna, Maria V. Cremona, Fernando Alvarenga, Ruth Perucca, Astor Lopez, Federico Miranda, Ditmar B. Kurtz   +26 more
doaj   +1 more source

Model engine data sheets and operating instructions, E - F, ca. 1950, 1991-1993, 1997, 1999

, 1950
Operating instructions and parts list for the Feeney 4-Cycle model ...
Feeny Engine Company
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Biophysics-based protein language models for protein engineering

Nature Methods
Abstract Protein language models trained on evolutionary data have emerged as powerful tools for predictive problems involving protein sequence, structure and function. However, these models overlook decades of research into biophysical factors governing protein function.
Sam Gelman, Bryce Johnson, Chase R. Freschlin, Arnav Sharma, Sameer D’Costa, John Peters, Anthony Gitter, Philip A. Romero   +7 more
openaire   +4 more sources