Results 71 to 80 of about 1,099,223 (288)

Web-based computational chemistry education with CHARMMing II: Coarse-grained protein folding. [PDF]

open access: yesPLoS Computational Biology, 2014
A lesson utilizing a coarse-grained (CG) Gō-like model has been implemented into the CHARMM INterface and Graphics (CHARMMing) web portal (www.charmming.org) to the Chemistry at HARvard Macromolecular Mechanics (CHARMM) molecular simulation package ...
Frank C Pickard   +5 more
doaj   +1 more source

Impact of Biophysical Mechanisms on Urban Heat Island Associated with Climate Variation and Urban Morphology

open access: yesScientific Reports, 2019
The rapid development of urban areas can potentially alter hydro-meteorological fluxes and lead to the Urban Heat Island (UHI) phenomenon. In this study, UHI intensity and its driving factors were estimated using the Community Land Model (CLM) in cities ...
Ressy Fitria   +3 more
semanticscholar   +1 more source

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

open access: yesInternational Journal of Molecular Sciences, 2020
Certain G-quadruplex forming guanine-rich oligonucleotides (GROs), including AS1411, are endowed with cancer-selective antiproliferative activity. They are known to bind to nucleolin protein, resulting in the inhibition of nucleolin-mediated phenomena ...
A. Ogloblina   +9 more
semanticscholar   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

open access: yesAdvanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe   +4 more
wiley   +1 more source

Long-term potentiation mechanism of biological postsynaptic activity in neuro-inspired halide perovskite memristors

open access: yesNeuromorphic Computing and Engineering, 2023
Perovskite memristors have emerged as leading contenders in brain-inspired neuromorphic electronics. Although these devices have been shown to accurately reproduce synaptic dynamics, they pose challenges for in-depth understanding of the underlying ...
Enrique Hernández-Balaguera   +6 more
doaj   +1 more source

Hierarchical self-assembly of a reflectin-derived peptide

open access: yesFrontiers in Chemistry, 2023
Reflectins are a family of intrinsically disordered proteins involved in cephalopod camouflage, making them an interesting source for bioinspired optical materials.
Ana Margarida Gonçalves Carvalho Dias   +20 more
doaj   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

open access: yesAdvanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song   +8 more
wiley   +1 more source

Biophysics and vegetation cover change: a process-based evaluation framework for confronting land surface models with satellite observations [PDF]

open access: yesEarth System Science Data, 2018
Land use and land cover change (LULCC) alter the biophysical properties of the Earth's surface. The associated changes in vegetation cover can perturb the local surface energy balance, which in turn can affect the local climate. The sign and magnitude
G. Duveiller   +11 more
doaj   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

open access: yesAdvanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar   +6 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

open access: yesAdvanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu   +7 more
wiley   +1 more source

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