Results 41 to 50 of about 243,368 (266)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
PathophysiologyThe vagina is an essential component of the female reproductive system and is responsible for providing female sexual satisfaction. Vaginal smooth muscle contraction plays a crucial role in various physiological processes, including sexual arousal ...
Chitaranjan Mahapatra, Ravinder Kumar
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Progress in Biophysics and Biophysical Chemistry [PDF]
Nature, 1956 Progress in Biophysics and Biophysical Chemistry Edited by Prof. J. A. V. Butler and Prof. J. T. Randall. Vol. 5. (Progress Series.) Pp. viii + 231 + 9 plates. (London and New York: Pergamon Press, Ltd., 1955.) 55s. net.
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STAR ProtocolsSummary: Optogenetic manipulation has proven a powerful tool for investigating the mechanisms underlying the function of neuronal networks, but implementing the technique on mammals during early development remains challenging.
Yu-Nan Chen +3 more
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Journal of Marine Science and Engineering, 2019 Tropical cyclone induced phytoplankton productivity is examined using a tropical cyclone version of the Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS®).
Travis A. Smith +3 more
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Entropy-based tuning of musical instruments [PDF]
Revista Brasileira de Ensino de Física, 2012 The human sense of hearing perceives a combination of sounds 'in tune' if the corresponding harmonic spectra are correlated, meaning that the neuronal excitation pattern in the inner ear exhibits some kind of order.
Haye Hinrichsen
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CHIMIA, 2010 Biophysical chemistry at the Department of Chemistry, University of Basel, covers the NMR analysis of protein–protein interaction using paramagnetic tags and sophisticated microscopy techniques investigating the dynamics of biological matter.
Häussinger, Daniel, Pfohl, Thomas
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Biophysics of Mechanotransduction [PDF]
European Biophysics Journal, 2015 (Singer and Nicolson 1972). As a physical barrier it presents a major target of mechanical forces stretching, compressing, bending or even breaking it, if an excessive force is acting on it. As a composite of a large variety of lipid molecules such as phospholipids, sphingolipids, cholesterol and many others, the lipid bilayer of the cell membrane ...
Boris, Martinac, Andrew R, Battle
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