Results 41 to 50 of about 441,621 (301)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Partial differential equations in medical biophysics [PDF]

, 1982
A number of examples of collaborative research are outlined which show how mathematicians and medical biophysicists have contributed to a wider understanding of some problems in applied ...
Twizell, E H
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Old habits die hard? How to challenge students and professors to rethink the teaching and learning processes in biophysics using escape room-based games

Advances in Physiology Education
One primary challenge in basic health program courses like biophysics is engaging students who struggle to connect initial concepts with future professional practice, leading to a lack of commitment to learning biophysics.
Thaís Busatto Crestani, Mariana Tamborindeguy, Fernanda Bordignon Nunes, Maria Beatriz Fonte Kohek, Gisele Branchini   +4 more
doaj   +1 more source

Predicting Secondary Structures, Contact Numbers, and Residue-wise Contact Orders of Native Protein Structure from Amino Acid Sequence by Critical Random Networks

, 2005
Prediction of one-dimensional protein structures such as secondary structures and contact numbers is useful for the three-dimensional structure prediction and important for the understanding of sequence-structure relationship.
Altschul, S. F., Madden, T. L., Sch, Baldi, P., Brunak, S., Frasconi, P., CHANDONIA J-M, Crooks, G. E. &, Kinjo, A. R. &, Kinjo, A. R. &, Kinjo, A. R., Horimoto, K. &, Lee, B. &, Li, W., Jaroszewski, L. &, Nishikawa, K. &, Pollastri, G., Baldi, P., Fariselli, Rost, B., TATENO Y   +12 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Half a century of biophysics: A comparison of presentation statistics from the 6th and 21st IUPAB Congresses

Biophysics and Physicobiology
This is a report on the participation in the IUPAB Congress held in Kyoto in 1978 and 2024 by two senior members of the Biophysical Society of Japan who had the fortunate opportunity to attend the two Congresses.
Mikio Kataoka, Kuniaki Nagayama
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source