Results 51 to 60 of about 298,837 (307)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PathophysiologyThe vagina is an essential component of the female reproductive system and is responsible for providing female sexual satisfaction. Vaginal smooth muscle contraction plays a crucial role in various physiological processes, including sexual arousal ...
Chitaranjan Mahapatra, Ravinder Kumar
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Proposal to Abolish the Division of Sensory Biophysics
, 2006 This document contains the proposal to abolish the Division of Sensory ...
Ohio State University. College of the Arts and Sciences. Division of Sensory Biophysics
core +1 more source
STAR ProtocolsSummary: Optogenetic manipulation has proven a powerful tool for investigating the mechanisms underlying the function of neuronal networks, but implementing the technique on mammals during early development remains challenging.
Yu-Nan Chen +3 more
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Journal of Marine Science and Engineering, 2019 Tropical cyclone induced phytoplankton productivity is examined using a tropical cyclone version of the Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS®).
Travis A. Smith +3 more
doaj +1 more source
Entropy-based tuning of musical instruments [PDF]
Revista Brasileira de Ensino de Física, 2012 The human sense of hearing perceives a combination of sounds 'in tune' if the corresponding harmonic spectra are correlated, meaning that the neuronal excitation pattern in the inner ear exhibits some kind of order.
Haye Hinrichsen
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Molecules, 2014 Avidin and avidin-like proteins are widely used in numerous techniques since the avidin-biotin interaction is known to be very robust and reliable. Within this study, we investigated this bond at the molecular level under harsh conditions ranging from ...
Melanie Köhler +6 more
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