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Special Issue on “Advances in Bioprocess Technology” [PDF]

This Special Issue, “Advances in Bioprocess Technology”, focuses on the latest advancements in sustainable bioprocess technologies [...
Alessandra Procentese, Francesca Raganati   +1 more
core   +1 more source

Mechanistic deconvolution of BSA size variants by constrained Raman pseudo‐Voigt hard modeling during anion‐exchange chromatography

Biotechnology Progress, EarlyView.
Abstract In biopharmaceutical manufacturing, protein aggregation is a critical quality attribute, necessitating rapid and reliable analytical strategies during downstream processes like anion‐exchange chromatography (AEX). While Raman spectroscopy enables continuous monitoring of protein secondary structure, standard data‐driven regression models ...
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

CFD: A New Challenge in Bioprocess Engineering

, 2018
Computational Fluid Dynamics (CFD) is a powerful tool based on mathematical applications for modeling transient and spatial transport modes such as mass, momentum and heat transfer in multiphase fluids.
Gelves, German, Niño, Lilibeth, Peñuela, Mariana, Niño López, Lilibeth   +3 more
core  

Application of commercial ultrafiltration membranes for protein purification by high performance countercurrent membrane purification (HPCMP)

Biotechnology Progress, EarlyView.
Abstract High performance countercurrent membrane purification (HPCMP) has emerged as a promising diffusive separation strategy for the purification of recombinant proteins and monoclonal antibodies (mAbs). However, prior studies employed dialysis membranes, which are designed for diffusive separations but have not been validated for biopharmaceutical ...
Aylin Mohammadzadehmarandi, Nate Heller, Mohammadreza Ahmadimashhadi, Jon Petrone, Nicholas Marchand, Siavash Darvishmanesh, Ka Zhang, Stefano Menegatti, Andrew L. Zydney   +8 more
wiley   +1 more source

Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses

Biotechnology Progress, EarlyView.
Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing, Tomoki Igi, Daniel Strauss   +2 more
wiley   +1 more source

Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing

Engineering in Life Sciences
Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds.
Alperen Alpural, Ilgin Kimiz‐Gebologlu, Mayur Parekh, Esra Imamoglu, Zulfiqur Ali, Ozlem Yesil‐Celiktas   +5 more
doaj   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Impact of single‐use bioreactor bag materials on Spodoptera frugiperda cell expansion for recombinant adeno‐associated virus manufacturing

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate‐scale bioreactors to large‐scale production.
Min Tae Park, Seyed Pouria Motevalian
wiley   +1 more source

Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development

, 2019
Design of Experiments methods offer systematic tools for bioprocess development in Quality by Design, but their major drawback is the user-defined choice of factor boundary values.
Steinmetz, Tobias, Koopmann, Kirsten, Pörtner, Ralf, Kuchemüller, Kim Beatrice, Möller, Johannes   +4 more
core   +1 more source

Development of Liquid Biofertilizer by Unveiling the Potential of Statistical Modeling Approaches in Scalable Laboratory Batch Bioprocess for Rhizobium WG Strain

Liquid biofertilizers have gained the prominence over chemical fertilizers and have become crucial agents to enhance the crop productivity in sustainable agricultural approaches.
K. Sanjeev Kumar, Ananth Aparna, S. Jeevan Chandra, Pavan Kumar Pindi   +3 more
core   +1 more source