Results 1 to 10 of about 4,632 (176)

Antibacterial Evaluation of Tricyclic Antidepressants Against S. aureus and the Possible Pathways of the Mechanism of Action [PDF]

Pathogens
The resistance of Staphylococcus aureus to conventional pharmacological treatments has gradually increased. Thus, new therapeutic strategies are needed.
Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, Cecília Rocha da Silva, João Batista de Andrade Neto, Érica Rayanne Mota da Costa, Thais Lima Ferreira, Leilson Carvalho de Oliveira, Beatriz Oliveira de Souza, Dávylla Rênnia Saldanha Pinheiro, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior   +14 more
doaj   +2 more sources

Characterization of mycobacteria isolated from the Brazilian Atlantic Forest: a public health and bioprospection perspective. [PDF]

Front Microbiol
The Mycobacterium genus remains highly relevant today due to the rising incidence of tuberculosis and opportunistic infections caused by environmental mycobacteria. While much is known about M. tuberculosis, M. leprae and M.
Emmerick LS, Schwarz MGA, Corrêa PR, Piñero SL, Gomes LHF, Almeida AMM, Valente RH, Degrave WMS, Mendonça-Lima L.   +8 more
europepmc   +2 more sources

Strategies to facilitate the bioprospection of properties of agronomic interest in microbial culture collections and a successful case of selection to mitigate drought stress in maize. [PDF]

BMC Microbiol
The replacement of synthetic molecules with biological solutions has been a global goal with high priority in agriculture. Worldwide, there are several well-organized microbial collections holding high biodiversity and biotechnological potential.
Vasques NC, Cerezini P, Torres AR, Nogueira MA, Hungria M.   +4 more
europepmc   +2 more sources

The Link Between the Ecology of the Prokaryotic Rare Biosphere and Its Biotechnological Potential [PDF]

Frontiers in Microbiology, 2020
Current research on the prokaryotic low abundance taxa, the prokaryotic rare biosphere, is growing, leading to a greater understanding of the mechanisms underlying organismal rarity and its relevance in ecology.
Francisco Pascoal, Francisco Pascoal, Catarina Magalhães, Catarina Magalhães, Catarina Magalhães, Catarina Magalhães, Rodrigo Costa, Rodrigo Costa, Rodrigo Costa, Rodrigo Costa   +9 more
doaj   +3 more sources

<i>In Silico</i> Bioprospection of <i>Daniellia oliveri-</i>Based Products as Quorum Sensing Modulators of <i>Escherichia coli</i> SdiA. [PDF]

Biochem Res Int
Escherichia coli is a common pathogen responsible for various gut-related infections, and it utilizes the SdiA-mediated quorum sensing (QS) system to regulate biofilm formation, other virulence factors, and pathogenicity.
Dweba Y, Eleojo Aruwa C, Sabiu S.
europepmc   +2 more sources

Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity [PDF]

Frontiers in Pharmacology
BackgroundGut immunity plays a critical role in overall health by balancing tolerance to food antigens and microbiota while defending against pathogens. Inflammation and infection in the gut can disrupt this balance, leading to disease.
Vidushi Tyagi, Vidushi Tyagi, Ashish Kumar, Karuna Shanker, Anirban Pal, Anirban Pal   +5 more
doaj   +2 more sources

Novel CaLB-like Lipase Found Using ProspectBIO, a Software for Genome-Based Bioprospection [PDF]

BioTech, 2023
Enzymes have been highly demanded in diverse applications such as in the food, pharmaceutical, and industrial fuel sectors. Thus, in silico bioprospecting emerges as an efficient strategy for discovering new enzyme candidates.
Gabriela C. Brêda, Priscila E. Faria, Yuri S. Rodrigues, Priscila B. Pinheiro, Maria Clara R. Nucci, Pau Ferrer, Denise M. G. Freire, Rodrigo V. Almeida, Rafael D. Mesquita   +8 more
doaj   +2 more sources

Bioprospection of indigenous herbal formulations for diabetes care: in vitro, network pharmacology, and molecular dynamics studies. [PDF]

BMC Complement Med Ther
Herbal formulations have garnered significant interest from researchers for their potential antidiabetic effects. However, scientific validation of their efficacy and understanding of their mechanisms of action have limited their use in modern medicine ...
Ojo OA, Ogunlakin AD, Ajayi-Odoko OA, Gyebi GA, Ayokunle DI, Olanrewaju AA, Agbeye OD, Ogunwale ET, Adeyemi OS.   +8 more
europepmc   +2 more sources

Bioprospection of <i>Hura crepitans</i> metabolites against oxidative stress and inflammation: An <i>in vitro</i> and <i>in silico</i> exploration. [PDF]

Int J Med Sci
Background: Despite the recognized therapeutic potential of Hura crepitans, its mechanistic antioxidant and anti-inflammatory actions remain underexplored.
Kuo YC, Lawal B, Lukman HY, Chen LC, Huang SL, Chen YF, Fadaka AO, Olawale F, Olasupo A, Ajenifujah OT, Fouad D, Papadakis M, Batiha GE, Sabiu S, Wu ATH, Huang HS.   +15 more
europepmc   +2 more sources

Systematic bioprospection for cellulolytic actinomycetes in the Chihuahuan Desert: isolation and enzymatic profiling. [PDF]

PeerJ, 2023
The quest for microbial cellulases has intensified as a response to global challenges in biofuel production. The efficient deconstruction of lignocellulosic biomass holds promise for generating valuable products in various industries such as food ...
Escudero-Agudelo J, Martínez-Villalobos J, Arocha-Garza H, Galán-Wong LJ, Avilés-Arnaut H, De la Torre-Zavala S.   +5 more
europepmc   +2 more sources