Results 141 to 150 of about 116,881 (292)

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

Head &Neck, EarlyView.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi, James A. Stewart, Kirk Withrow, Carissa M. Thomas   +3 more
wiley   +1 more source

Detection of PTEN Mutations in Fine Needle Aspiration Biopsies of Indeterminate Thyroid Nodules: Impact on Diagnosis and Prognosis

Head &Neck, EarlyView.
ABSTRACT Background Data connecting PTEN mutations with thyroid cancer risk for indeterminate nodules remain limited due to the rare nature of these mutations. The aim of this study was to determine the relationship between PTEN mutations identified in cytologically indeterminate nodules and final pathology and clinical outcomes.
Lauren E. Schlegel, Madelaine Brill‐Edwards, Zi‐Xuan Wang, Christopher McNair, Stacey Gargano, Elizabeth Cottrill   +5 more
wiley   +1 more source

Emerging Proximal Liquid Biopsy Approaches for Detecting Residual Disease and Predicting Recurrence in Head and Neck Cancer: A Review and Proposal of Novel Liquid Staging

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma remains challenging due to high recurrence rates and poor survival outcomes. Developing precise technologies for disease burden assessment, treatment response, and minimal residual disease (MRD) surveillance is crucial for improving prognosis. Methods This review explores the potential of liquid
Vanessa Helou, Joshua D. Smith, Micah Harris, Noah Earland, Kevin J. Contrera, Aadel A. Chaudhuri, Jose P. Zevallos   +6 more
wiley   +1 more source

The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1)

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This study demonstrated the novel compound heterozygous mutations (NM_000137: c.657delC (p.K220Rfs*12) and NM_000137: c.607G>A(p.A203T)) in FAH gene in a patient were responsible for HT1. We showed these FAH mutations were inherited in an autosomal recessive manner and resulted in abnormal FAH protein expression and dysfunction, leading to ...
Huan Chi, Chun Gan, Yaru Jiang, Dan Chen, Jiawen Qiu, Qing Yang, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li   +10 more
wiley   +1 more source

Bilateral Thyroid Ima Arteries Arising From the Brachiocephalic Trunk: A First Case Report

Head &Neck, EarlyView.
ABSTRACT Rationale Bilateral thyroid ima artery (TIA) arising from the brachiocephalic trunk is an extremely rare anatomical variation, with no prior cases reported. Recognizing such vascular anomalies is crucial for optimizing surgical outcomes in thyroid and mediastinal procedures, as failure to identify these variations can lead to severe ...
Ziqiang Wang, Deguang Zhang, Qiwei Du, Weijun Zhang, Nian Liu, Rongguo Li   +5 more
wiley   +1 more source

Accurate and Minimally Invasive Cervical Pedicle Screw Insertion Procedure Using the Bone Biopsy Needle as Drill Guide. [PDF]

Spine Surg Relat Res, 2020
Koakutsu T, Aizawa T, Itoi E.
europepmc   +1 more source

HPV‐Positive Squamous Cell Carcinoma Metastasis Without Clinical Evidence of Primary: The Posterior Oropharyngeal Wall May Be an Overlooked Location

Head &Neck, EarlyView.
ABSTRACT Background Oropharyngeal squamous cell carcinoma (SCC) can present as cancer of unknown primary, where only cervical lymph node metastases are identified. Most tumors, particularly human‐papillomavirus‐associated ones, are located in the palatine/lingual tonsils.
Sannia Sjöstedt, Martin Garset‐Zamani, Kirsten Korsholm, Tina Klitmøller Agander, Tobias Todsen, Irene Wessel   +5 more
wiley   +1 more source

Patterns of Initial Lymph Node Involvement and Recurrence in Patients With Maxillary Sinus Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Determining whether to treat the elective cervical lymph node (LN) area remains a dilemma in maxillary sinus squamous cell carcinoma (SCC). This study analyzed the patterns of initial LN involvement and recurrence to guide treatment strategies. Methods We retrospectively reviewed 119 patients with maxillary sinus SCC treated between
Jina Kim, Chan Woo Wee, Chang Geol Lee, Ki Chang Keum, Kyung Hwan Kim   +4 more
wiley   +1 more source

Advances in analytical microfluidic workflows for differential cancer diagnosis

Nano Select, Volume 4, Issue 1, Page 1-47, January 2023., 2023
Microfluidics holds a great potential for an analytical examination of liquid biopsy and the development of point‐of‐care testing devices. This review overviews fundamentals and technological breakthroughs of immunolabeled and label‐free analytical microfluidic devices for screening and examining CTCs, describes engineering‐driven workflows for ...
Morteza Hasanzadeh Kafshgari, Oliver Hayden   +1 more
wiley   +1 more source

Time to pathologic diagnosis of suspicious breast lesions: An institution‐based study in five Ethiopian hospitals

International Journal of Cancer, EarlyView.
What's New? The World Health Organization's Global Breast Cancer Initiative set the benchmark to diagnose breast cancer within 2 months of the first contact with a health care provider. This study analyzed the diagnostic journey of women with breast symptoms at five Ethiopian hospitals. Of the 345 women interviewed who received a diagnostic workup of a
Friedemann Rabe, Sefonias Getachew, Clara Yolanda Stroetmann, Nikolaus Christian Simon Mezger, Tewodros Yalew Gebremariam, Bereket Berhane, Alex Mremi, Blandina Theophil Mmbaga, Pauline Boucheron, Valerie McCormack, Pablo Santos, Adamu Addissie, Eva Johanna Kantelhardt   +12 more
wiley   +1 more source