Results 141 to 150 of about 214,700 (310)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović   +11 more
wiley   +1 more source

Prospective study of EUS-guided tissue acquisition with a 20G core biopsy needle with a forward bevel for solid pancreatic mass. [PDF]

open access: yesMedicine (Baltimore), 2021
Kanata R   +9 more
europepmc   +1 more source

Use of the Ion Robot in the Diagnosis of Pulmonary Nodules: Fine Needle Aspiration Versus Cryobiopsy

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Background Robotic‐assisted bronchoscopy platforms provide an innovative approach to the sampling of pulmonary nodules. As compared to other technologies, fiber‐optic shape‐sensing instrumentation allows for a more precise, accurate location and sampling of the target lesion with fewer complications.
Suzanne M. Selvaggi
wiley   +1 more source

Effectiveness of introducing a 20-gauge core biopsy needle with a core trap in EUS-FNA/B for diagnosing pancreatic cancer. [PDF]

open access: yesBMC Gastroenterol, 2021
Watanabe S   +14 more
europepmc   +1 more source

Cumulative Cytological Assessment of Repeated Non‐Diagnostic Thyroid Fine Needle Aspirations: A Novel Approach to Reduce Diagnostic Uncertainty

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Purpose Fine needle aspiration (FNA) is the primary diagnostic tool for evaluating thyroid nodules. However, 10%–21% of FNAs yield non‐diagnostic (ND) results (Bethesda category I). Repeated ND findings occur in 25%–67.5% of cases, creating diagnostic uncertainty and increased healthcare costs.
Shiri Damti Geva   +7 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

How Would You Treat? A Case‐Vignette Study of Provider Treatment Preferences in Human Papillomavirus‐Mediated Oropharyngeal Cancer

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Current guidelines recommend surgical resection, definitive radiotherapy (RT), or concurrent chemoradiotherapy (CRT) for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (OPSCC). This study aimed to provide insight into practice patterns of providers who treat HPV‐associated OPSCC.
Sindhura Sridhar   +2 more
wiley   +1 more source

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