Results 131 to 140 of about 71,391 (320)
Bayesian Optimization in Bioprocess Engineering—Where Do We Stand Today?
Biotechnology and Bioengineering, EarlyView.ABSTRACT Bayesian optimization is a stochastic, global black‐box optimization algorithm. By combining Machine Learning with decision‐making, the algorithm can optimally utilize information gained during experimentation to plan further experiments—while balancing exploration and exploitation.
Florian Gisperg +5 more
wiley +1 more source
Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023 Abstract In nature, microorganisms often reside in symbiotic co‐existence providing nutrition, stability, and protection for each partner by applying “division of labor.” This principle may also be used for the overproduction of targeted compounds in bioprocesses.
Tobias Müller +4 more
wiley +1 more source
Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process
Biotechnology and Bioengineering, EarlyView.ABSTRACT Increasing demand for recombinant adeno‐associated virus (rAAV)‐based gene therapies necessitates increased manufacturing production. Transient transfection of mammalian cells remains the most commonly used method to produce clinical‐grade rAAVs due to its ease of implementation.
Tam N. T. Nguyen +11 more
wiley +1 more source
An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023 Abstract Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational particles (parcels), provide information on environmental gradients inside bioreactors from the microbial perspective. Such information is highly relevant for reactor scale‐down and process optimization.
Cees Haringa
wiley +1 more source
Bioreactor Development for Production of Viral Pesticides or Heterologous Proteins in Insect Cell Culturesa [PDF]
, 1990 Michael L. Shuler +7 more
openalex +1 more source
Single Cell Protein Production From Ethanol: Model‐Based Bioreactor Operation at Industrial Scale
Biotechnology and Bioengineering, EarlyView.ABSTRACT Alternative fermentation feedstocks such as ethanol can be produced from CO2 via electrocatalytic processes that coproduce O2. In this study, industrial‐scale fermentation of ethanol with pure O2 for single cell protein (SCP) production was studied using a modeling approach.
Eduardo Almeida Benalcázar +6 more
wiley +1 more source
Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)
Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023 Abstract Biopharmaceutical production processes often use mammalian cells in bioreactors larger than 10,000 L, where gradients of shear stress, substrate, dissolved oxygen and carbon dioxide, and pH are likely to occur. As former tissue cells, producer cell lines such as Chinese hamster ovary (CHO) cells sensitively respond to these mixing ...
Lena Gaugler +5 more
wiley +1 more source
Growth of Vero E-6 cells on microcarriers in a cell bioreactor [PDF]
, 1990 L A White, Edwin W. Ades
openalex +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green +9 more
wiley +1 more source
Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023 Abstract Biotechnological production processes are sustainable approaches for the production of biobased components such as amino acids for food and feed industry. Scale‐up from ideal lab‐scale bioreactors to large‐scale processes is often accompanied by loss in productivity.
Manh Dat Hoang +5 more
wiley +1 more source