Results 131 to 140 of about 6,069,719 (250)
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract The search for alternative and sustainable energy sources becomes urgent as energy demand increases and fossil fuels become less available, especially in water‐scarce regions such as the Brazilian semi‐arid region, where current projections of global warming and the expansion of arid and semi‐arid zones point to a future of desertification ...
Wallysson K. P. Barros +10 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino +6 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner +7 more
wiley +1 more source
Ciência Florestal, 2016 The plant micro-propagation in bioreactor systems is regarded as one way to reduce cost by automation and production scheduling. This research was carried out in order to obtain an efficient procedure for clone production of Eucalyptus
Evânia Galvão Mendonça +5 more
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What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
wiley +1 more source
A Method for Optical Quantification of Local Oxygen Limitations in Multiphase Bioreactors
Biotechnology and Bioengineering, EarlyView.ABSTRACT Spatial oxygen limitation is a major source of physiological stress and metabolic, scale‐dependent heterogeneity in aerobic bioprocesses. In gas‐liquid stirred tank reactors, oxygen availability is governed by hydrodynamics and mass transfer and is therefore inherently non‐uniform.
Ryan Rautenbach +5 more
wiley +1 more source
LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim +4 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens +2 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
Media improvement for 10 L bioreactor production of rPOXA 1B laccase by P. pastoris. [PDF]
3 Biotech, 2019 Ardila-Leal LD +11 more
europepmc +1 more source