Results 191 to 200 of about 126,870 (331)

A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn   +4 more
wiley   +1 more source

Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease. [PDF]

Gut Microbes
Newman KL, Standke AK, James G, Vendrov KC, Inohara N, Bergin IL, Higgins PDR, Rao K, Young VB, Kamada N.   +9 more
europepmc   +1 more source

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

Biotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse, Fabian Schmitz, Janina Kilian, Jonas Austerjost, Lucas‐Nik Reger, Markus Kampmann   +5 more
wiley   +1 more source

Autotrophic and Mixotrophic Batch Processes with <i>Clostridium autoethanogenum</i> LAbrini in Stirred Tank Bioreactors with Continuous Gassing. [PDF]

Microorganisms
Oppelt A, Nguyen TYN, Zhang Y, Weuster-Botz D.   +3 more
europepmc   +1 more source

Customization of an optical probe device and validation of a signal processing procedure to study gas–liquid–solid flows. Application to a three-phase internal-loop gas-lift Bioreactor

, 2015
André Mota, António Ferreira, António A. Vicente, Philippe Séchet, Jean Martins, J. A. Teixeira, Alain H. Cartellier   +6 more
openalex   +2 more sources

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, EarlyView.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

Performance Of Membrane Bioreactor (Mbr) In High Phosphate Wastewater

, 2013
M. I. Aida Isma, A. R. Putri Razreena, Rozita Omar, Azni Idris   +3 more
openalex   +1 more source

Mixing and oxygen transfer characteristics of a microplate bioreactor with surface‐attached microposts

, 2021
Justin Fisher, Travis O. Gurney, Brittany M. Mason, Jay K. Fisher, William J. Kelly   +4 more
openalex   +2 more sources

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source

Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation. [PDF]

Front Bioeng Biotechnol
Springuel P, Silva Couto P, Stibbs DJ, Szelwicki M, Frangleton A, Schmidberger T, George A, Slingsby F, Bevan N, Ahmad A, Legmann R, Dianat N, Ladi R, Hengst J, Rafiq QA.   +14 more
europepmc   +1 more source