Results 191 to 200 of about 92,761 (280)

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

Effects of bioreactor inoculation method on secondary metabolite production and morphological characteristics of Streptomyces rimosus in microparticle-enhanced cultivation (MPEC). [PDF]

Microb Cell Fact
Ścigaczewska A, Boruta T, Bizukojć M.
europepmc   +1 more source

Innovative methodology for flexible monitoring of various bioprocesses by using pre‐existing Raman data coupled with automated transfer learning technique

Biotechnology Progress, EarlyView.
The application of the transfer learning algorithm successfully allowed the use of a model built on process A for real‐time monitoring of process B. This study shows the improvement obtained with this methodology compared to the direct application of the model.
Adèle Schini, Hadi El Radi, Johan Cailletaud, Célia Sanchez, Nathan Gay, Bruno Ebel, Emmanuel Guedon, Laurent Jourdainne   +7 more
wiley   +1 more source

The Impact of Large-Scale Expansion on the Functional Properties of Mesenchymal Stem Cells. [PDF]

Stem Cell Rev Rep
Antonio-Ríos G, Ribas-Aparicio RM, Leyva-Gómez G, Soldevila G, Dueñas KAE, Trejo-Iriarte CG, González-Torres M.   +6 more
europepmc   +1 more source

Design of experiments‐guided membrane capture facilitates integration of continuous virus inactivation using Phi6 as a surrogate virus in an intensified downstream process

Biotechnology Progress, EarlyView.
Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg, Lisa Lipski, Gabriel Fisicaro, Thomas Duvignau, Karolina Meyer‐Heinrichs, Diana Carmen Mocsy, Thomas‐Josef Filz, Bastian Quaas, Alexandra Stützer   +8 more
wiley   +1 more source

Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production. [PDF]

Biotechnol Bioeng
Gadiyar CJ, Müller C, Vuillemin T, Bielser JM, Souquet J, Fagnani A, Sokolov M, von Stosch M, Feidl F, Butté A, Cruz Bournazou MN.   +10 more
europepmc   +1 more source

Economic and environmental implications of the development of UASB reactors in Mexico for sustainable industrial wastewater treatment

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The objective of this work is to demonstrate that the inclusion of an up‐flow anaerobic sludge bed (UASB reactor) within an industrial wastewater treatment plant reduces the plant's investment and operating costs compared to a system based solely on conventional complete‐mix activated sludge (CMAS), operating under the same design principles ...
Juan Manuel Morgan‐Sagastume, Adalberto Noyola   +1 more
wiley   +1 more source

Enrichment and characterization of steroid-degrading microbes for targeted removal of steroid hormone micropollutants in small-scale wastewater treatment solutions. [PDF]

Microbiol Spectr
Kujala K, Nübel LL, Philipp B, Holert J.   +3 more
europepmc   +1 more source

Valorization of Juice Industry Waste Into Foam‐Like Materials Using Mycelium as Natural Binder

CleanMat, EarlyView.
This study explores converting carrot pomace, a juice industry byproduct, into eco‐friendly mycelium‐based foams using Aspergillus oryzae. The foams, produced via submerged cultivation, grinding and freeze‐drying, showed promising mechanical properties comparable to commercial foams, offering a sustainable alternative to synthetics while promoting ...
S. Najmeh Mousavi, Paula Pou I Rodríguez, Juliana Aristéia de Lima, E. R. Kanishka B. Wijayarathna, Sunil Kumar Ramamoorthy, Minna Hakkarainen, Akram Zamani   +6 more
wiley   +1 more source

Advanced Biomaterial-Based In Vitro Osteoarthritis Models: Integrating Sex as a Biological Variable in Hormonal, Subchondral Bone, and Mechanobiological Pathways. [PDF]

J Funct Biomater
Capuana E, De Luca A, Costa V, Raimondi L, Bellavia D, Brucato V, Giavaresi G, La Carrubba V.   +7 more
europepmc   +1 more source