Results 211 to 220 of about 111,398 (363)

A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines

open access: yesBiotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin   +5 more
wiley   +1 more source

Charting the landscape of the environmental exposome

open access: yesiMeta, Volume 1, Issue 4, December 2022., 2022
We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei   +6 more
wiley   +1 more source

Synthetic modeling: A cell‐free approach for faster implementation of Raman spectroscopy in cell culture

open access: yesBiotechnology Progress, EarlyView.
Abstract Monitoring cell culture is crucial for gaining a deeper understanding of processes and ensuring the production of safe and high‐quality products. The capability to measure in real time several parameters of interest can be achieved with Raman spectroscopy.
Célia Sanchez   +6 more
wiley   +1 more source

A study on the convergence of observer-based kinetics estimators in stirred tank bioreactors [PDF]

open access: green, 1996
Rui Oliveira   +3 more
openalex   +1 more source

Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems

open access: yes, 2019
Anderlei, T.   +6 more
core   +1 more source

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

open access: yesBiotechnology Progress, EarlyView.
Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire   +5 more
wiley   +1 more source

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