Results 41 to 50 of about 58,775 (305)

Unbaffled, Stirred Bioreactors for Animal Cell Cultivation

, 2017
One of the main features of animal cell bioreactors is that the cultured cells lack a strong membrane and are therefore more prone to shear damage. It is widely accepted that animal cell damage in aerated bioreactors is mainly related to burst bubbles at
A. Brucato, BRUCATO, Alberto, SCARGIALI, Francesca, Scargiali, F., Busciglio, A, Brucato, A., F. Scargiali, BUSCIGLIO, ANTONIO, A. Busciglio   +8 more
core   +1 more source

Numerical study of substrate assimilation by a microorganism exposed to fluctuating concentration [PDF]

, 2012
In most modelling works on bioreactors, the substrate assimilation is computed from the volume average concentration. The possible occurrence of a competition between the transport of substrate towards the cell and the assimilation at the cell level is ...
Martins Afonso, Marco, Morchain, Jérôme, Linkès, Marion, Fede, Pascal, Schmitz, Philippe   +4 more
core   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

Airlift Bioreactors - Bioreactors Design

, 2011
Producción ...
Guieysse, Benoit, Quijano Govantes, Guillermo, Muñoz Torre, Raúl   +2 more
openaire   +3 more sources

Harnessing Physiological Shear Stress in a Perfusion Bioreactor for Enhanced Endothelialization of Small‐Diameter Vascular Grafts

Advanced NanoBiomed Research
This study presents a versatile perfusion bioreactor system designed to evaluate endothelialization on electrospun polycaprolactone (PCL)–gelatin vascular grafts under controlled flow conditions that mimic physiological and pathological shear stress. The
Praveesuda L. Michael, Yuen Ting Lam, Timothy C. Mitchell, Miguel Santos, Alex H. P. Chan, Xinying Liu, Angus J. Grant, Matthew J. Moore, David F. Fletcher, Richard P. Tan, Steven G. Wise   +10 more
doaj   +1 more source

Characterization of the Metabolic Response of Streptomyces clavuligerus to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production

Antibiotics, 2019
Streptomyces clavuligerus is a gram-positive filamentous bacterium notable for producing clavulanic acid (CA), an inhibitor of β-lactamase enzymes, which confers resistance to bacteria against several antibiotics.
David Gómez-Ríos, Stefan Junne, Peter Neubauer, Silvia Ochoa, Rigoberto Ríos-Estepa, Howard Ramírez-Malule   +5 more
doaj   +1 more source

Biopharmaceutical-Type Chinese Hamster Ovary Cell Cultivation Under Static Magnetic Field Exposure: A Study of Genotoxic Effect

Frontiers in Bioengineering and Biotechnology, 2021
The lack of a sufficient research base is the reason for the ongoing discussion regarding the genotoxic effect of magnetic field (MF) exposure on mammalian cell cultures.
Alina Rekena, Dora Livkisa, Edmunds Kamolins, Edmunds Kamolins, Juris Vanags, Dagnija Loca, Dagnija Loca   +6 more
doaj   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up

, 2013
During the past 10 years, single-use bioreactors have been well accepted in modern biopharmaceutical production processes targeting high-value products.
Eibl-Schindler, Regine, Eibl, Dieter, Dieter Eibl, Löffelholz, Christian, Matthias Kraume, Stephan C. Kaiser, Kaiser, Stephan C., Kraume, Matthias, Regine Eibl, Christian Löffelholz, Eibl D, Kraume M, Kaiser SC, Löffelholz C, Eibl R   +14 more
core   +1 more source