Results 151 to 160 of about 50,173 (296)
The FEBS Journal, EarlyView.In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou +6 more
wiley +1 more source
The FEBS Journal, EarlyView.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito +8 more
wiley +1 more source
The FEBS Journal, EarlyView.The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami +6 more
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research
Insect Molecular Biology, EarlyView.Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung +5 more
wiley +1 more source
Aquaculture policy options for integrated resource management in SubSaharan Africa: extended abstracts and discussions [PDF]
This volume contains brief papers which review the socioeconomic and biophysical environment in which integrated aquaculture must function in subSaharan Africa; presentations of experiences from research and the field, including both biotechnical and ...
Brummet, R.E. (ed.)
core
Journal of Integrative Plant Biology, EarlyView.In neo‐tetraploid rice, the NTRF1–SAPK2 heat shock protein–kinase module coordinates abscisic acid signaling with reactive oxygen species homeostasis to ensure timely tapetal programmed cell death and subsequent pollen maturation, providing a resource for the genetic improvement of polyploid rice.
Lichong Cao +7 more
wiley +1 more source