Results 151 to 160 of about 7,502,466 (284)

Absence of a Hectocotylus and Associated Mating Behaviour in the Paintpot Cuttlefish Ascarosepion tullbergi

Acta Zoologica, EarlyView.
ABSTRACT A hectocotylus is a sexually modified arm used by males of some cephalopod species to transfer spermatophores to females. In most cuttlefish (Sepiidae), it corresponds to the left arm IV, in which basal suckers are reduced or absent; this modification is thought to facilitate sperm transfer without premature rupture, which could be caused by ...
Ayano Omura, Shin‐ichiro Oka, Taketeru Tomita, Haruka Takano, Daisuke Funabara   +4 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Cooperation in Bioresource Management Problems

, 2017
in Contributions to game theory and management, vol. X. Collected papers presented on the Tenth International Conference Game Theory and Management / Editors Leon A. Petrosyan, Nikolay A. Zenkevich. – SPb.: Saint Petersburg State University, 2017.
Rettieva, Anna N.
core  

An inhibitor of the mitochondrial respiratory chain exerts synergistic anti‐tumour effects when combined with alkylating agents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cancer cells exhibit the Warburg effect, but oxidative phosphorylation (OXPHOS) is also important for cancer cell proliferation. Metabolic reprogramming from glycolysis to OXPHOS is one mechanism of resistance to anti‐tumour drugs.
Emiri Omori Takaki, Yuya Hidoh, Yutaka Obuchi, Yoko Nagai, Shingo Nishikori, Yuki Kuniyoshi, Yasuhiro Sawai, Naoto Ohi   +7 more
wiley   +1 more source

Myofibroblast‐Like CAFs in Metastatic Lymph Nodes Drive Tumor Stemness and Poor Prognosis in Head and Neck Cancer

Cancer Science, EarlyView.
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara, Hideyuki Takahashi, Reika Kawabata‐Iwakawa, Miho Uchida, Hiroe Tada, Toshiyuki Matsuyama, Masaomi Motegi, Yuichi Tomidokoro, Kazuaki Chikamatsu   +8 more
wiley   +1 more source

Study of Nanocellulose Fibrils. Derived from Bioresource Waste: Reduction of Agglomeration and Cross-linking.

, 2016
The research was intended to study the nanofibrils obtained from bioresource waste (palm oil empty fruit bunches). The azide-alkyne click chemistry was used as a tool to modified the nanofibrils.
Yhaya, Mohd Firdaus
core   +1 more source

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Cancer Science, EarlyView.
Psychological stress promotes hepatocellular carcinoma progression through coordinated regulation of macrophages and neutrophils. Noradrenaline activates ADRB2 signaling in intratumoral macrophages, leading to CXCL2 production and neutrophil recruitment.
Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi   +13 more
wiley   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Oxalis pes-caprae L. (Oxalidaceae): From Invasive Concern to Promising Bioresource for Health and Sustainable Applications

Oxalis pes-caprae L., an invasive plant from South Africa, has developed into a severe ecological threat in many Mediterranean and temperate areas by replacing native flora and modifying ecosystems.
Giuseppe Antonio Malfa, Claudia Di Giacomo, Francesco Maria Raimondo, Vivienne Spadaro, Simone Bianchi, Rosaria Acquaviva, Spadaro, Vivienne, Acquaviva, Rosaria, Bianchi, Simone, Maria Raimondo, Francesco, DI GIACOMO, Claudia, Malfa, Giuseppe   +11 more
core   +1 more source

Integrated Transcriptomics of Human and Canine Osteosarcoma Reveals Species Stemness and Trabectedin Sensitivity

Cancer Science, EarlyView.
Comprehensive comparative molecular framework for human and canine osteosarcomas. Integrated transcriptomic analyses establish a comprehensive comparative molecular framework for human and canine osteosarcomas. By defining species‐specific stemness architectures and drug response dynamics, our findings highlight the necessity of accounting for distinct
Kenta Kono, Yomogi Shiota, Ting‐Ting Shu, Hayato Shibahara, Daiki Kato, Takayuki Nakagawa, Seiji Ohtori, Tadashi Kondo   +7 more
wiley   +1 more source