Results 161 to 170 of about 7,502,466 (284)

High ZFP36 Family Expression in Exhausted T Cells Is Associated With Impaired Antitumor Effector Function

Cancer Science, EarlyView.
Hypoxia induces ZFP36 family expression in exhausted CD8+ T cells, promoting the decay of AU‐rich effector cytokine mRNAs and suppressing TNF, IL2, and IFNG expression, thereby potentially contributing to impaired antitumor effector function. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by reinvigorating antitumor ...
Li Zhu, Youki Ueda, Yu Inutsuka, Toshifumi Ninomiya, Yuka Saeki, Takashi Inozume, Hiroko Watanabe, Takamasa Ishino, Hiroyoshi Y. Tanaka, Kazuo Yamashita, Masakiyo Sakaguchi, Joji Nagasaki, Yosuke Togashi   +12 more
wiley   +1 more source

Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor‐State Heterogeneity and an MMP12+ Macrophage Niche

Cancer Science, EarlyView.
Spatial transcriptomic profiling of SCLC revealed marked intratumoral heterogeneity, including coexisting neuroendocrine and non‐neuroendocrine states and spatially heterogeneous hypoxia, and identified an MMP12+ macrophage population enriched at hypoxic and necrotic tumor interfaces.
Naozane Nomura, Naoe Jimbo, Takaaki Nakanishi, Yukinobu Ito, Maki Sakaguchi, Daichi Maeda, Hiroko Ikeda, Tsukasa Ueda, Hayato Koba, Seiji Yano, Isao Matsumoto, Patrick Micke, Takayuki Kodama, Manabu Shigeoka, Yu‐ichiro Koma, Masafumi Horie   +15 more
wiley   +1 more source

Valuing local water quality in Ontario using revealed preference data

Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie, EarlyView.
Abstract Improving water quality is an important goal for policymakers, yet understanding the economic benefits people receive from changes in water quality is challenging because many of the benefits are non‐market in nature. We use spatially explicit lake Secchi disk depth measures and information on over 320,000 property sales to provide the most ...
Tharaka A. Jayalath, Patrick Lloyd‐Smith, Richard Vyn   +2 more
wiley   +1 more source

Complete genome sequence of <i>Anaerocolumna</i> sp. MB42-C2 isolated from a hot spring in Qingliu, Fujian, China. [PDF]

Microbiol Resour Announc
Zhao J, Lin Y, Wu C-H, Chen S-C, Qiu W, Dong G, Shih C-J, Wu Y-C, Xiao W.   +8 more
europepmc   +1 more source

First genomic analysis of Platycopioida and phylogenomics across six copepod orders

Cladistics, EarlyView.
Abstract Recent advances in bioinformatics have significantly expanded our understanding of the genetic properties of organisms and have provided valuable insights into their phylogenetic relationships and evolutionary histories. However, molecular phylogenetic studies of the class Copepoda remain limited, and the focus has been mainly on the major ...
Donggu Jeon, Chi‐une Song, Junil Ko, Yusuke Kondo, Kenji Toyota, Man‐Ki Jeong, Ho Young Soh, Susumu Ohtsuka, Seong‐il Eyun   +8 more
wiley   +1 more source

Complete genome sequence of <i>Tissierella</i> sp. strain MB52-C2 isolated from a soil sample from Wuyi Mountain. [PDF]

Microbiol Resour Announc
Ming Y, Li Y, Ma Y, Zhao J, Dong G, Qiu W, Shih C-J, Wu Y-C, Wu C-H, Lai S-J, Xiao W, Zhao Y, Chen S-C.   +12 more
europepmc   +1 more source

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Developmental Medicine &Child Neurology, EarlyView.
We present 10 patients who presented with acute onset axonal neuropathy following infection, mimicking childhood axonal Guillain–Barré syndrome. We review phenotypes, undertake survival analysis, and assess function of novel RCC1 variants in vitro. Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who ...
Han Zhang, Beril Din, John H. McDermott, RCC1 Neuropathy Study Group, Adam Jackson, Halil Tuna Akar, Ali Dursun, Riza Koksal‐Ozgul, Reza Sadjadi, Lauren Politica, Stephan Zuchner, Reza Maroofian, Usman Ali, Dudu Turkyilmaz, Jawadur Rahman, Hasan Bas, Khalid Hussain, Khalid A Fakhro, Aljazi Al‐Maraghi, Annemarie CS Knijnenburg, Monique Engel, Debby Hellebrekers, Heike Losch, Sietse M Aukema, Marlene Kullik, Christoph Geier, Raymond T. O'Keefe, William G. Newman, J. Robert Harkness   +28 more
wiley   +1 more source

DYNAMICS OF EGG PRODUCTION IN CHICKENS OF VARIOUS BREEDS OF BIORESOURCE COLLECTIONS

Polythematic Online Scientific Journal of Kuban State Agrarian University, 2018
O. V. Mitrofanova, N. V. Dementeva
openaire   +1 more source

Headache disorders among Indigenous communities: A scoping review undertaken with knowledge keeper guidance

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective We performed a scoping review of literature on headache etiology, classification, prevalence, and treatment in Indigenous communities in Canada, the United States, Australia, and New Zealand. Background In the United States, analysis of national prevalence indicates that Indigenous Americans lead all other racial/ethnic groups in ...
Maia Kelly, Candice M. Todd, Ojistoh Kahnawahere Horn, Emily Simmonds, Diane Longboat, Cynthia White, Suvendrini Lena   +6 more
wiley   +1 more source

Recent achievements of the National Center Biobank Network (NCBN) bioresources through Japanese fiscal year 2025. [PDF]

Front Genet
Omae Y, Tokunaga K.
europepmc   +1 more source