Results 211 to 220 of about 49,736 (242)

Inhibition of IL‐6/STAT3 Signaling by N‐Trans‐Hibiscusamide and Its Derivative in a Mouse Model of Collagen‐Induced Arthritis

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
The IL‐6/STAT3 axis is crucial in rheumatoid arthritis (RA) via Th17 differentiation. The IL‐6/STAT3 signaling pathway is downregulated as a result of the inhibition of IL‐6 and IL‐6R binding by NHA and NAD. NHA and NAD decrease the Th17 differentiation, which lessens the severity of CIA.
Hyung Jin Lim, Seon Gyeong Bak, Jaehoon Bae, Nisansala Chandimali, Eun Jae Park, Seung Woong Lee, Mingyeong Kim, Sang‐Hoon Lee, Yeong‐Seon Won, Sun Hee Cheong, Seung‐Jae Lee   +10 more
wiley   +1 more source

Professional biobanking education in Korea based on ISO 20387. [PDF]

J Pathol Transl Med
Kim JO, Kim C, Song S, Shin E, Song JS, Roh MS, Kim DC, Kim HK, Kim JM, Choi YJ.   +9 more
europepmc   +1 more source

Boscisucrophage: A Natural SGLT1/2 Inhibitor From Boscia senegalensis for Managing Type 2 Diabetes

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Boscisucrophage (BSP) significantly reduced blood glucose and HbA1c, increased urine glucose excretion, and improved functional symptoms in T2DM patients resistant to oral antihyperglycemic drugs. BSP showed no adverse effects on liver or kidney function.
Bruno Eto, Amal Elrherabi, Fahd A. Nasr, Joe Miantezila Basilua, Ahlam Outman, Rosette Christelle Ndjip, Mohamed Bouhrim, Mohammed Al‐zharani, Ashraf Ahmed Qurtam, Brahim Ibet, Bernard Gressier, Jehan‐François Desjeux   +11 more
wiley   +1 more source

Long-Read Spatial Transcriptomics of Patient-Derived Clear Cell Renal Cell Carcinoma Organoids Identifies Heterogeneity and Transcriptional Remodelling Following NUC-7738 Treatment. [PDF]

Cancers (Basel)
Abdullah H, Zhang Y, Kirkwood K, Laird A, Mullen P, Harrison DJ, Elshani M.   +6 more
europepmc   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

Machine learning and AI-Assisted red blood cell morphology analysis for effective thalassemia screening. [PDF]

Ann Hematol
Gui Y, Chen W, Su Y, Qin C, Zhang F, Zhao J, Liu Q.   +6 more
europepmc   +1 more source

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, Volume 158, Issue 5, Page 1336-1347, 1 March 2026.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

Complete genomes and plasmid profiles of five <i>Lactococcus</i> isolates from Japanese amberjack (<i>Seriola quinqueradiata</i>) and greater amberjack (<i>Seriola dumerili</i>) cultured in Japan. [PDF]

Microbiol Resour Announc
Maiga S, Ogawa R, Imajoh M.
europepmc   +1 more source

Convergent evolution of metabolic functions: Evidence from the gut microbiomes of humans and dogs

iMetaOmics, Volume 3, Issue 1, March 2026.
Dogs have undergone convergent evolution in their genome with humans in long‐term co‐living. Studies have shown that the gut microbiomes of dogs exhibit greater similarity to those of humans compared to mice and pigs. In our study, we first compared the gut microbiomes of macaques, three dog groups, and two wolf groups to those in humans.
Xiaoyang Wang, Lei Zhu, Yue Lan, Guimei Li, Tong Zhou, Qingguo Huang, Tifei Yuan, Chen Tian, Zhenxin Fan, Zhigang Zhang, Guo‐Dong Wang   +10 more
wiley   +1 more source

Genetic basis of latitudinal variation in vertebral number in the Oryzias latipes species complex. [PDF]

Zoological Lett
Hara R, Ansai S, Kamei Y, Matsuda M, Kinoshita M.   +4 more
europepmc   +1 more source