Results 31 to 40 of about 162,481 (277)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research on prominent biosafety issues in the field of public health in China: a review

Zhongguo gonggong weisheng, 2023
On October 17, 2020, China officially passed the Biosafety Law of the People's Republic of China, which lists biosecurity as an important part of national security and clarifies the important status of biosafety.
Qifan YANG, Yuping WANG
doaj   +1 more source

Cisgenesis: an important sub-invention for traditional plant breeding companies [PDF]

, 2009
Modern plant breeding is highly dependent on new technologies to master future problems. More traits have to be combined, frequently originating from wild species. Traditional breeding is connected with linkage drag problems.
Jacobsen, E., Schouten, H.J.
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

International liability and redress for genetically modified organisms and challenge for China's biosafety regulation [PDF]

, 2012
The UN Cartagena Protocol on Biosafety (Biosafety Protocol) is an international instrument addressing the potential environment and health issues of Genetically Modified Organisms (GMOs).
Xiang, Wen
core  

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Environmental risk assessment of genetically modified plants - concepts and controversies [PDF]

, 2011
Background and purpose: In Europe, the EU Directive 2001/18/EC lays out the main provisions of environmental risk assessment (ERA) of genetically modified (GM) organisms that are interpreted very differently by different stakeholders. The purpose of this
A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Lang, A Raps, A Raybould, A Raybould, AL Cerdeira, ANE Birch, B Lutz, C Hawes, C Zwahlen, C Zwahlen, CB Blackwood, CBD, Council of the European Union, D Saxena, DA Andow, DA Andow, DA Andow, DJ Baird, EC, EC, EFSA, EJ Rosi-Marshall, Environmental Protection Agency (EPA), EP Millstone, EPA Environmental Protection Agency OPPTS 7501P, EurActive, FAO/WHO, J Romeis, J Romeis, J Romeis, J Scheirs, JD Harwood, JD Harwood, KC Nelson, KC Nelson, KR Hayes, KR Hayes, LB Obrist, M Dolezel, M Douville, M Garcia-Alonso, M Mendelsohn, MC Arregui, MR Berenbaum, National Research Council (NRC), OECD, OECD (Organisation for Economic Cooperation and Development), PM Chapman, Royal Society of Canada, T Bøhn, VE Forbes, W Freese   +57 more
core   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Genome-scale analyses of transcriptional start sites in Mycobacterium marinum under normoxic and hypoxic conditions

BMC Genomics, 2021
Background Hypoxic stress plays a critical role in the persistence of Mycobacterium tuberculosis (Mtb) infection, but the mechanisms underlying this adaptive response remain ill defined. Material and methods In this study, using M. marinum as a surrogate,
Shaojia Huang, Wei Zhou, Wei Tang, Yong Zhang, Yangbo Hu, Shiyun Chen   +5 more
doaj   +1 more source

Scientific innovation for the sustainable development of African agriculture [PDF]

, 2019
The African continent has considerable potential to reap the benefits associated with modern agricultural biotechnology. Plant biotechnology and breeding represent an invaluable toolbox to face the challenges of African agriculture, such as food and ...
De Bauw, Vanessa, De Buck, Sylvie, De Oliveira, Dulce, Diasolua Ngudi, Delphin, Gheysen, Godelieve, Heijde, Marc, Lambein, Fernand, Travella, Silvia, Van Montagu, Marc   +8 more
core   +1 more source