Results 21 to 30 of about 132,140 (253)

Thoughts on biosafety education of experimental course of pathogenic biology under COVID-19 epidemic situation [PDF]

Jichu yixue yu linchuang, 2020
The current COVID-19 epidemic situation is grim, and the government has realized the importance of biosafety. This paper summarizes the situation and experience of biosafety management and education in pathogenic biology teaching laboratory from the ...
ZHANG Zhuo-yang, YUAN Zhen-dong, YANG Yang, YANG He-ping, XIAO Jia-qi, ZHAO Wei
doaj  

Assessment of the Biosafety and Biosecurity Landscape in the Philippines and the Development of the National Biorisk Management Framework

, 2021
Introduction: The emergence of biological threats that can potentially affect millions emphasizes the need to develop a policy framework in the Philippines that can mount an adequate and well-coordinated response. The objective of the study was to assess,
Destura, Raul V., Lopez, Jaifred Christian F., Lam, Hilton Y, Sales, Reneepearl Kim P, Gomez, Ma. Ida Faye A., dela Tonga, Angelo, Navarro, Rohani C, Gomez, Ma Ida Faye A, Destura, Raul V, Sales, Reneepearl Kim P., Lam, Hilton Y., Ulanday, Gianne Eduard, Lopez, Jaifred Christian F, Navarro, Rohani C., Hilton Y. Lam, Angelo dela Tonga, Gianne Eduard Ulanday, Reneepearl Kim P. Sales, Jaifred Christian F. Lopez, Raul V. Destura, Ma. Ida Faye A. Gomez, Rohani C. Navarro   +21 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Domestic Implementation of the Cartgena Protocol in Kenya and South Africa: A comparative analysis [PDF]

, 2014
This comparative study sought to answer the following key research question: to what extent are current and proposed biosafety legislations in Kenya and South Africa consistent with or at variance with key provisions of the Cartagena Protocol on ...
Mouitui, Charles Otuke
core   +1 more source

REGULATING BIOSAFETY OF GENETICALLY MODIFIED CROPS IN INDONESIA: LIMITS AND CHALLENGES

UUM Journal of Legal Studies, 2021
The global use of genetically modified (GM) crops is rapidly expanding. While the advent of this agricultural biotechnology offers new promises to cater to the rising demand for Indonesia’s food security, the government should ensure its safety.
Muhammad Bahrul Ulum
doaj   +5 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Methodological validation of a cryo-TEM-based detection method for empty capsid ratio in recombinant adeno-associated virus

Biochemistry and Biophysics Reports
Recombinant adeno-associated virus (rAAV) is one of the most promising vectors for gene therapy. It consists of a protein capsid that encapsulates the genetic material.
Lingyi Xu, Jinhuan Chen, Wei Zhu, Yaokun Zhao, Fangfang Zheng, Rong Du, Yuwei Jiang, Yidan Yang, Yuanyuan Chen, Yuanshu Dong, Zhengxi Zhang, Yong Tong   +11 more
doaj   +1 more source

Strengthening regulatory capacity for gene drives in Africa: leveraging NEPAD’s experience in establishing regulatory systems for medicines and GM crops in Africa

BMC Proceedings, 2018
The New Partnership for Africa’s Development (NEPAD) Agency recognizes that Africa is in a period of transition and that this demands exploring and harnessing safe advances made in science-based innovations including modern biotechnology.
Barbara Glover, Olalekan Akinbo, Moussa Savadogo, Samuel Timpo, Godwin Lemgo, Woldeyesus Sinebo, Sunday Akile, Silas Obukosia, Jeremy Ouedraogo, Margareth Ndomondo-Sigonda, Muffy Koch, Diran Makinde, Aggrey Ambali   +12 more
doaj   +1 more source

Investigation and analysis of the biosafety awareness of laboratory staff involved in the detection of pathogens in seven provincial Centers for Disease Control and Prevention in China

Biosafety and Health, 2021
This study aims to evaluate the biosafety awareness of laboratory staff working on pathogens detection in seven Centers for Disease Control and Prevention and support these staff's biosafety management and training.
Yan Liu, Yuanyuan Guo, Sisi Li, Bo Liu, Jing Wen, Chihong Zhao   +5 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source