Results 51 to 60 of about 117,129 (304)

Biosafety risk assessment and management of laboratory-derived influenza A (H5N1) viruses transmissible in ferrets

, 2013
Highly pathogenic avian influenza (HPAI) A (H5N1) viruses occasionally infect humans, but currently do not transmit efficiently among them. However, the risk for human pandemic influenza is a major concern should these viruses acquire the capacity for ...
A. Baldo, S. Welby, B. Van Vaerenbergh, A. Leunda, C.D. Do Thi, D. Breyer, P. Herman, K. Pauwels   +7 more
core   +1 more source

Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice

Journal of Virology
Increasing numbers of studies have highlighted the important implications of the replication fidelity of RNA viruses for virus replication, pathogenesis, and the development of antiviral drugs and live-attenuated vaccines.
Fang Yu, Dongyan Xiong, Yao Zhong, Qiu-Yan Zhang, Cheng-Lin Deng, Zhe-Rui Zhang, Chang Wang, Yang Qiu, Han-Qing Ye, Peng Gong, Bo Zhang   +10 more
doaj   +1 more source

Tratando as nanopartículas com precaução: reconhecendo a incerteza qualitativa na avaliação científica do risco

Política & Sociedade, 2012
Invenções científicas e tecnologias, como a nanotecnologia, interagem com sistemas ecológicos e sociais complexos em vários níveis e têm o potencial de causar consequências ímpares e sem precedentes.
Fern Wickson, Froydis Gillund, Anne Ingeborg Myhr   +2 more
doaj   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Transparency as Contested Political Terrain: Who Knows What about the Global GMO Trade and Why does it Matter?

, 2010
This article explores the prospects for transparency to be a transformative force in global biosafety governance. It analyzes whether information disclosure can further a right to know and choose, and hence facilitate oversight over transnational ...
Aarti Gupta, Gupta, A.
core   +1 more source

Laboratory biosafety manual, fourth edition [PDF]

, 2020
xviiForewordThe first edition of the World Health Organization (WHO) Laboratory biosafety manualwas published in 1983. It encouraged countries to accept and implement basic concepts in biological safety and to develop national codes of practice for the ...

core  

Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model

Journal of Neuroinflammation
Background Dengue encephalitis, a severe neurological complication of dengue virus infection, is increasingly recognized for its rising incidence and significant public health burden.
Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li   +11 more
doaj   +1 more source

Promoting biotechnology applications in China through effective biosafety education and communication

GM Crops & Food
Biosafety represents a widespread but alarming terminology in life sciences. It was originally created for safety issues related to the possible leakage of recombinant DNAs from laboratories.
Ying Wang, Bao-Rong Lu
doaj   +1 more source