Results 71 to 80 of about 105,302 (256)
Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense
Advanced ScienceInterferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1.
Zhen Tong +4 more
doaj +1 more source
Phage–Bacterial Interaction Alters Phenotypes Associated with Virulence in Acinetobacter baumannii
VirusesBacteriophages exert strong selection on their bacterial hosts to evolve resistance. At the same time, the fitness costs on bacteria following phage resistance may change their virulence, which may affect the therapeutic outcomes of phage therapy.
Greater Kayode Oyejobi +6 more
doaj +1 more source
Dynamic Disulfide Ionogels for Self‐Healing, Transparent, and Elastic E‐Skins
Advanced Materials Technologies, EarlyView.A dynamic covalent ionogel is designed via polymer–ionic liquid interaction control. The interplay between ionic liquid compatibility, viscosity, and concentration governs polymer segmental dynamics, which in turn regulates disulfide exchange kinetics and mechanical durability.
Min Su Kim +6 more
wiley +1 more source
Role of Src family kinases Fyn and Lyn in arenavirus infection
Journal of VirologyArenaviruses encompass a diverse group of infectious agents, some of which, like Lassa virus (LASV), pose significant threats to global public health due to their acute virulence, while others, such as lymphocytic choriomeningitis virus (LCMV), are less ...
Wenting Mao +11 more
doaj +1 more source
Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots
Advanced Robotics Research, EarlyView.This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou +4 more
wiley +1 more source
Biosafety challenges and the future landscape in Pakistan
Khyber Medical University JournalSepsis is a major threat to global health, as highlighted by the Global Burden of Disease Study, which recorded an estimated 48.9 million cases of sepsis globally, resulting in 11.0 million sepsis-related deaths, accounting for 19.7% of all global deaths
Akhtar Sherin
doaj +1 more source
Advanced Robotics Research, EarlyView.Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin +3 more
wiley +1 more source
Orapuh JournalIntroduction In biomedical laboratories, biosafety is a key element for preventing infections and ensuring the safety of healthcare workers and the community.
Diane Sare Gamani +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang +6 more
wiley +1 more source
Ultrasound‐Actuated Gene Editing in Human Kidney Organoids
Advanced Science, EarlyView.Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller +6 more
wiley +1 more source