Results 81 to 90 of about 117,129 (304)

Domestic Implementation of the Cartgena Protocol in Kenya and South Africa: A comparative analysis

, 2014
This comparative study sought to answer the following key research question: to what extent are current and proposed biosafety legislations in Kenya and South Africa consistent with or at variance with key provisions of the Cartagena Protocol on ...
Mouitui, Charles Otuke
core  

Natural variation in tocopherols, B vitamins, and isoflavones in seeds of 13 Korean conventional soybean varieties

Applied Biological Chemistry
Soybean seeds are excellent sources of tocopherols, B vitamins, and isoflavones, which are well known for their health benefits. This study investigated the influence of environment and genotype on these constituents across 13 Korean soybean varieties ...
Eun-Ha Kim, Jung-Won Jung, Oh Suk Yu, So-Young Lee, Myeong-Ji Kim, Sang-Gu Lee, Hyoun-Min Park, Yongmin Jo, Yongsung Joo, Seon-Woo Oh   +9 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

2’-5’ Oligoadenylate Synthetase-Like 1- (OASL1-) deficient mice promote antiviral protection against pseudorabies virus infection associated with enhanced production of type I interferon

Scientific Reports
Pseudorabies virus (PRV) infects various mammals and causes Aujeszky’s disease, posing a significant threat to the pig industry. The interaction between PRV and the host’s innate immune system, however, remains poorly understood.
Tien Huyen Ton Nu Bao, Mwense Leya, Thach Phan Van, Gaeul Ham, ByungKwan Oh, Sang-Ik Oh, Won-Il Kim, Seok-Chan Park, Bumseok Kim   +8 more
doaj   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Iowa Seed & Biosafety News (Vol. 22, No. 2)

, 2005
Contents: New DNA lab at the Seed Science Center; Seed Science Center and BIGMAP profiles; Risks and benefits of growing pharmaceutical corn in the Corn Belt; Amateur philosophy corner attitudes to biotech; 2004 biosafety news headlines; Development of ...

core  

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Signal Transduction and Targeted Therapy, 2022
Hong-Qing Zhang, Ya-Nan Zhang, Zhe-Rui Zhang, Xiao-Ling Chen, Yan-Yan Hu, Yu-Jia Shi, Jing Wang, Cheng-lin Deng, Bo Zhang, Xiao-Dan Li, Han-Qing Ye   +10 more
doaj   +1 more source

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Advanced Science
Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1.
Zhen Tong, Jia‐Peng Zou, Su‐Yun Wang, Wei‐Wei Luo, Yan‐Yi Wang   +4 more
doaj   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source