Results 231 to 240 of about 35,640 (270)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Why implementation gaps could undermine synthetic nucleic acid oversight. [PDF]

Front Bioeng Biotechnol
Gillum DR, Moritz RL.
europepmc   +1 more source

A bioeconomy for Latin America and the Caribbean: opportunities and challenges from a policy perspective [PDF]

, 2011
Henry, Guy, Ingelbrecht, Ivan, Revel, Clara, Rocha, Pedro, Sanders, Johan, Santana, Carlos, Schurr, Ulrich, Trigo, Eduardo J.   +7 more
core  

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Preliminary assessment of drug repurposing against virus-associated primary effusion lymphoma. [PDF]

J Microbiol Biol Educ
Plaza D, Chefitz G, McKiernan ER, Sandler SE, Levrero C, Kim K, Germano ER, Braner S, Ariyan LA, Miranda JL.   +9 more
europepmc   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Challenges, opportunities, and future perspectives of portable field endoscopy. [PDF]

Mil Med Res
He K, Wang SY, Ren J.
europepmc   +1 more source

Pandemic flu guidance : higher and further education institutions [PDF]

, 2009

core  

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Biosafety concept: Origins, Evolution, and Prospects. [PDF]

Biosaf Health
Gao W, Wu Z, Zuo K, Xiang Q, Chen X, Zhang L, Liu H.   +6 more
europepmc   +1 more source