Results 71 to 80 of about 5,348,273 (263)

Biosafety, biosecurity, and bioethics

Monash Bioethics Review
The COVID-19 pandemic has highlighted the importance of biosafety in the biomedical sciences. While it is often assumed that biosafety is a purely technical matter that has little to do with philosophy or the humanities, biosafety raises important ...
David B. Resnik
semanticscholar   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Combined exposure risk of emamectin benzoate and cyantraniliprole mixture to nonalcoholic fatty liver disease

Ecotoxicology and Environmental Safety
Evidence links pesticides to nonalcoholic fatty liver disease (NAFLD), but the combined effects of dietary pesticide residue mixture exposure on NAFLD remain poorly documented.
Yuying Liu, Zhiyong Cao, Li Zhang, Shujie Wang, Chang Chen, Tingting Meng, Ziqi Liu, Yanhong Shi, Jinjing Xiao   +8 more
doaj   +1 more source

Biosafety Training and Introduction to Livestock Diseases Using Participatory Rural Appraisal Method in Pade Angen Livestock Group East Lombok Regency

Jurnal Pengabdian UNDIKMA
The community service aims to introduce the application of biosafety and biosecurity and provide the ability to recognize livestock diseases simply with the participatory rural appraisal (PRA) method in reducing the transmission of livestock diseases in ...
Kholik Kholik, Munawer Pradana, Mariyam Al Haddar, N. Nofisulastri, K. H. P. Riwu, I. D. Dharmawibawa, Akhmad Sukri   +6 more
semanticscholar   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Tetraploid Formation from Open-Pollinated Triploid Loquat Provides a Promising Pathway for Large-Scale Seedless Breeding

Horticulturae
Triploid loquat (Eriobotrya japonica, 2n = 3x = 51) produces seedless fruit and holds significant breeding value. However, the scarcity of tetraploids hinders large-scale triploid propagation.
Tingting Meng, Haiyan Wang, Yilang Chen, Yingjia Liu, Meiyu Chen, Jingjing Dong, Haoxiang Zhu, Jiangbo Dang, Qigao Guo   +8 more
doaj   +1 more source

Ambit of biosafety governance in the sustainable food system

Journal of Applied Biotechnology & Bioengineering
Regulations and surveillance of health risks are addressed by different socio-economic sectors. The governance of biosecurity during the agroecological transition towards sustainable food has as its scope primary food production, complementary services ...
L. Vázquez
semanticscholar   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source