Results 31 to 40 of about 135,973 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Efficient on-chip electrochemical lysing of foodborne bacteria for longer DNA strands with high yield for molecular analysis

Scientific Reports
Foodborne illness is caused by the consumption of bacterial contaminated food and beverages. Diagnostic intervention in the form of point-of-care testing (PoCT) device is required for rapid detection bacteria.
Subasini Jayakanthan, Suneesh Punathil Vasu, Satheesh Babu TG   +2 more
doaj   +1 more source

Design and optimization of a microfiber coupler for biosensing

, 2013
We design and optimize a simple, low-cost and compact biosensor based upon a microfiber coupler, with a predicted sensitivity and detection limit up to S~104 nm/RIU and DL~10-6 RIU ...
Brambilla, Gilberto, Ismaeel, Rand, Ding, Ming, Melvin, Tracy, Lee, Timothy, Gouveia, Marcelo Alonso Botelho, Rand Ismaeel, Tracy Melvin, Timothy Lee, Gilberto Brambilla, Marcelo A. Gouveia, Ming Ding   +11 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A comparative study of enzyme immobilization strategies for multi-walled carbon nanotube glucose biosensors [PDF]

, 2011
This work addresses the comparison of different strategies for improving biosensor performance using nanomaterials. Glucose biosensors based on commonly applied enzyme immobilization approaches, including sol-gel encapsulation approaches and ...
Claussen, Jonathan C., Rickus, Jenna, D Marshall Porterfield, Percy Calvo-Marzal, McLamore, Eric S., Jenna L Rickus, Alfred R Diggs, Aeraj ul Haque, Jaroch, David, Eric S McLamore, ul Haque, Aeraj, Jin Shi, Shi, Jin, David Jaroch, Calvo-Marzal, Percy, Jonathan C Claussen, Diggs, Alfred, Porterfield, D. Marshall   +17 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A proof of concept of a BioMEMS glucose biosensor using microfabricated SU-8 films [PDF]

, 2009
The present project investigated and proved the concept of developing a novel BioMEMS glucose micro-biosensor using a simple one-step microfabrication process of the widely used SU-8 polymer.
Psoma, Sotiria D.
core   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Pathological In Vivo Analysis of Helicobacter DNA Infection in Stomach Cells Using Carbon Nanotube Microsensor

Microorganisms
The WHO has classified Helicobacter pylori as a group 1 carcinogen for stomach cancer since early 1994. However, despite the high prevalence of Helicobacter pylori infection, only about 3% of infected people eventually develop gastric cancer.Biomolecular
Kyung Lee, Sihyun Jun, Yeseul Oh, Seojun Lee, Ye Jun Oh, Keum Sook Kim, Suw Young Ly   +6 more
doaj   +1 more source

Evaluating the efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor

Microsystems & Nanoengineering, 2023
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality worldwide. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have dramatically improved the life expectancy of patients with NSCLC, concerns about ...
Deming Jiang, Xinwei Wei, Yuxuan Zhu, Yong Qiu, Xin Liu, Liubing Kong, Fengheng Li, Jingwen Liu, Liujing Zhuang, Hao Wan, Kejing Ying, Ping Wang   +11 more
doaj   +1 more source