Results 31 to 40 of about 201,023 (316)
In-situ profiling of glycosylation on single cells with surface plasmon resonance imaging
Nature CommunicationsCellular glycosylation is crucial for cell recognition, signal transduction, and the development of various diseases, especially in tumor initiation, progression, and metastasis.
Xiaoyin Liu +8 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Essays in Biochemistry, 2016 Optical biosensors represent the most common type of biosensor. Here we provide a brief classification, a description of underlying principles of operation and their bioanalytical applications. The main focus is placed on the most widely used optical biosensors which are surface plasmon resonance (SPR)-based biosensors including SPR imaging and ...
Damborský, Pavel +2 more
openaire +2 more sources
Italian National Conference on Sensors, 2020 Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases.
Feiyun Cui, Zhiru Zhou, H. Zhou
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Scientific ReportsFoodborne illness is caused by the consumption of bacterial contaminated food and beverages. Diagnostic intervention in the form of point-of-care testing (PoCT) device is required for rapid detection bacteria.
Subasini Jayakanthan +2 more
doaj +1 more source
Microneedle-based biosensor for minimally-invasive lactate detection.
Biosensors & bioelectronics, 2019 Here we report the first mediated microneedles-based biosensor for minimally invasive continuous sensing of lactate in the dermal interstitial fluid (ISF).
P. Bollella +3 more
semanticscholar +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
BiosensorsThe activated carbon from marigold flowers (MG) was used to make an unlabeled electrochemical immunosensor to determine prostate cancer. MG was synthesized by hydrothermal carbonization and pyrolysis.
Suparat Cotchim +4 more
doaj +1 more source
Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
Italian National Conference on Sensors, 2015 Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions
H. H. Nguyen +3 more
semanticscholar +1 more source