Results 161 to 170 of about 426,257 (254)
CYP2D6‐Guided Opioid Therapy for Chronic Pain: A Multi‐Center Pragmatic Randomized Controlled Trial
Clinical Pharmacology &Therapeutics, EarlyView.The analgesic effectiveness of several opioids depends on CYP2D6‐mediated metabolism to more active opioid receptor agonists. CYP2D6 activity is impacted by genetic variability and medications that inhibit CYP2D6. We conducted a pragmatic, multi‐center, randomized, controlled trial to determine whether CYP2D6‐guided opioid prescribing improves chronic ...Todd C. Skaar, Rachel A. Myers, Roger B. Fillingim, John T. Callaghan, Kerri L. Cavanaugh, Hrishikesh Chakraborty, Jordan F. Baye, Emily J. Cicali, Michael T. Eadon, Erica N. Elwood, Elizabeth C. Harris, Lindsay J. Hines, Khoa A. Nguyen, Michelle A. Ramos, Marc Rosenman, Azita Sadeghpour, Saskia Shuman, Rajbir Singh, Emma M. Tillman, Christina M. Wyatt, Carol R. Horowitz, Deepak Voora, Lori A. Orlando, Josh F. Peterson, Larisa H. Cavallari, Julie A. Johnson, Paul R. Dexter, on behalf of the IGNITE Pragmatic Trials Network, L Orlando, D Voora, C Horowitz, C Horowitz, N Calman, T Skaar, T Skaar, P Dexter, T Skaar, P Dexter, J Johnson, L Cavallari, J Johnson, L Cavallari, J Johnson, L Cavallari, K Blake, K Blake, K Blake, J Peterson, J Peterson, K Cavanaugh, R Singh, R Singh, L Hines, C Wyatt, H Chakraborty, Christina Wyatt, Geoff Ginsburg, Kady‐Ann Steen‐Burrell, Bhargav Adagarla, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Kristen Linney, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Ryanne Wu, Ruth Lehan, Tyffany Locklear, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Bart Ferket, Kenneth Fifer, Diane Hauser, Joseph Kannry, James Murrough, Aniwaa Owusu Obeng, Janet Seo, Tatiana Sabin, Nandini Shroff, Paul Dexter, Abi Colwell, Amy M. Breman, Zeruesenay Desta, Cathy Fulton, Jennelle C. Hodge, Sheryl Lynch, Jonathan Oliver, Victoria M. Pratt, Ross Robinson, Elizabeth Rowe, Jennifer Stuart, Emma Tillman, Ashley Vetor, Julie Johnson, Larisa Cavallari, Alexander Parker, Erica Elwood, Kathryn Blake, Emily Cicali, Kelsey Cook, Karam Diaby, Julio Duarte, Ben Duong, Karla Giron, Elizabeth Eddy, Julia Krutov, Carol Mathews, Haesuk Park, Robyn Nelson, Ryan Rhoden, Caroline Schlierle, Taylor Sullivan, Almut Winterstein, Kristen Wiisanen, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Jordan Baye, Michelle Benck, Chantel Bender, Sylvia Eluhu, Colette Free, Shane Gonnelly, Sarah Hedeen, Lindsay Hines, Steve Houtschilt, Michelle Liu, Salisha Marryshow, Nicole Neville, Natasha Petry, Sidd Pratap, Vernon Sherden, Kimberly Snell, Ana Tomescu, Megan Trietsch, James Walker, Deanna Web, Erin Whiting, Russell A. Wilke, Simona Volpi, Sarah Hutchison, Natalie Kucher, Ebony Madden, Jessica Reinach, Renee Rider, Ismail Safi, Ella Samer, Lori Orlando, Lani Banez, Lisa Bendz, Jackie Jordan, Ann McGee, Christina Nix, Lorraine Vergara, Tyler Colon, Aaishah Francis, Samantha Guagliardo, Najiba Khan, Camila Tan Lam, Michelle Sciarrino, Emma Maiman‐Stadtmauer, Sofia Medina‐Pardo, Ololade (Lola) Williams, Sheng Luo, Kevin Anstrom, Alicia Ellis, Stephen Ellis, Hwasoon Kim, Peter Merrill, Lilin She, Jennifer Shepherd, Saira Siddiqui, Jun Wen, Brittany Davis, John Howard, Alia Jamison, Lydia Joyner, Ellie Kiihne, Johnathan Oliver, Libbie Silverman, Jordan Sonneville Jennifer Stuart, Laurel Tokar, Neil Calman, Daviana Buck, Nicole Canchucaja Porshia Cook, Ariel Jacobs Danielle John, Mirta (Mimi) Milanes, Wambui Ngari, Megan Triestch, Abraham Garcia, Carol Gutierrez, Steven Houtschilt, Maria Lopez, Alan Mejia, Anaite Montes Bu, Deanna Webb, Sonja White, Ali Brewer, Brittni Deadrick, Alexis Meyer, Blair Svennes, Hana Al Alshaykh, Tala Basha, Asia Cobb, Brendon Cooper, Amanda Elchynski, Amanda Elsey, Anuksha Gotmare, Lauren Lemke, Arielle Nelson, Michael Read, Genevieve Rosier, Isabella Schultz, Chiara Chermont Spina, Joshua Terrell, Alexa Valko, Precious Williams, Tracy Leonard, David Smith, Marian Davis, Vincent Guerra, Jennifer Salo, Claudia Cartaya Torres, Jorge Valedon, Paola Nieves Viana, Jose Alonso, Jeffery Gainer, Morgan Howard, Fatoumata Kaba, Brianna Rivers, Liliana Serrano, Kimberly Vigal, ADeia Williams, Angelo Lazaro, Salisha Merryshow, Henry Ong, John Thomas Callaghan, Raheleh Rahimi Darabad, Daniel Getu, Katherine Huber, Judive Jocelyn, Robin Morman Li, Rosalena Muckle, Brandi Plunkett, Siegfried Schmidt, Evgenia Teal, Petra Townsend, Joshua R. Wellington +255 morewiley +1 more sourceConsiderations for the Integration of Clinical Trials and Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.As clinical decision‐making increasingly moves toward individualized and context‐specific treatment recommendations, reliance on any single evidence source, randomized or observational, may be insufficient. Principled integration of randomized controlled trials and real‐world data, grounded in explicit causal frameworks, offers a path toward evidence ...Sky Qiu, Charles E. Barr, Lauren Dang, Larry Han, Kajsa Kvist, Hana Lee, Andrew Mertens, Nerissa Nance, Lei Nie, Kara Rudolph, Xu Shi, Jens Tarp, Salina P. Waddy, Kenneth Wiley, Andy Wilson, Margot Lisa Jing Yann, Zhiwei Zhang, Tianyue Zhou, Maya Petersen, Mark van der Laan +19 morewiley +1 more sourceCorrection: Maternal Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Vaccination in Panama: A Retrospective Follow-Up Study. [PDF]
CureusLuca Quintero A, DeAntonio R, Fernandez Camargo I, Peralta Alvarado A, Escobar L, Ricci Perez B, Flores LA, Gadea C, Barrios S, Guillen E, De Avila A, Sevillano Giraldez JR. +11 moreeuropepmc +1 more sourceOverview of Regulatory Guidelines Related to Methods and Models for Small Populations
Clinical Pharmacology &Therapeutics, EarlyView.This paper provides an overview of approaches and related guidelines from the EMA, FDA, and ICH that are relevant for obtaining clinical evidence for small populations to support regulatory decision making. The approaches are grouped into three categories: (1) maximizing the attainable sample size, (2) adapting the trial design to deal with a small ...Laurens Sluijterman, Letao Li, Kristin E. Karlsson, Vincent Damotte, Sarah Zohar, Kit Roes, Joanna IntHout +6 morewiley +1 more sourceExcess Mortality Among Patients With Anorexia Nervosa Treated Involuntarily
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective
Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity and increased relative mortality compared to the general population. Involuntary treatment (IT) is implemented after exhausting voluntary treatment options. This study investigates mortality in patients with AN following IT, using IT as an indicator of patient Line Bager, Katrine Holde, Janne Tidselbak Larsen, Loa Clausen, Zeynep Yilmaz, Benjamin Mac Donald, Liselotte Vogdrup Petersen +6 morewiley +1 more sourceData science and artificial intelligence in biology, health, and healthcare
Journal of Clinical and Translational SciencePeter L. Elkin, Christopher Lindsell, Julio Facelli, Manisha Desai, Chunhua Weng, Heidi Spratt, Shari Messinger, Lemuel Russell Waitman, JaMor Hairston, Ruth O’Hara, Jareen Meinzen-Derr +10 moredoaj +1 more source
