Results 271 to 280 of about 1,464,623 (413)

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

open access: yesAdvanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang   +5 more
wiley   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

open access: yesAdvanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu   +4 more
wiley   +1 more source

Enhanced production of ergothioneine in Aspergillus oryzae. [PDF]

open access: yesAppl Microbiol Biotechnol
Wang L   +5 more
europepmc   +1 more source

The Biosynthesis of Squalene

open access: hybrid, 1953
Robert Langdon, Konrad Bloch
openalex   +1 more source

Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato

open access: yesAdvanced Science, EarlyView.
This study establishes that HY5, activated by low‐dose light, acts as a systemic signal to enhance tomato fruit quality by directly promoting carotenoid synthesis and sugar metabolism. These findings demonstrate HY5's mobility from leaves to fruits and its application potential through nighttime LED lighting, offering a practical strategy for crop ...
Jiachun Wang   +7 more
wiley   +1 more source

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

open access: yesAdvanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao   +9 more
wiley   +1 more source

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