Results 41 to 50 of about 681,288 (296)
Biosynthesis of alamethicin [PDF]
FEBS Letters, 1976 1. Introduction Alamethicin is a cyclic octadecapeptide containing 2-methylalanine (aminoisobutyric acid, Aib), an unusual component. All other constituent amino acids are in the Lform. It has the structure [I] : 1 2 3 4 5 Pro - Aib - Ala - Aib - Ala I Gin 18 (y) - Glu - Aib - Aib - Val 17 16 15 ...
H. Rindfleisch, Horst Kleinkauf
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
MicrobiologyOpen, 2020 The extreme halophilic archaeon, Haloferax mediterranei can accumulate polyhydroxyalkanoate (PHA) from different renewable resources. To enhance the biosynthesis and quality of PHA, H.
Diya Alsafadi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Journal of Biological Chemistry, 1955 The enzyme, which was named sucrose phosphorylase, has not been found in plant tissues (4), and thus the mechanism of sucrose synthesis remains obscure. Evidence obtained from tracer experiments led Buchanan et al. (5, 6) to assume that in plants sucrose phosphate is formed from UDPG’ and fructose-l-phosphate.
Cardini, Carlos E. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Engineering MicrobiologyPentalenolactone is a sesquiterpene antibiotic from Streptomyces. Its biosynthetic pathway has been elucidated, except for the oxidation of pentalen-13-al to 1-deoxypentalenic acid.
Jing Li +6 more
doaj +1 more source
The biosynthesis of dicoumarol [PDF]
Biochemical Journal, 1967 Micro-organisms have been isolated that can utilize o-coumaric acid as a sole carbon source with the subsequent production of 4-hydroxycoumarin and dicoumarol. One of these organisms, Penicillium jenseni, has been used to examine the biosynthesis of dicoumarol.
D M, Bellis, M S, Spring, J R, Stoker
openaire +3 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source