Results 241 to 250 of about 3,203,016 (289)

Functional insights into <i>Streptomyces</i> isolates containing both clavulanic acid-like and carbapenem biosynthetic gene clusters. [PDF]

mSphere
Tahlan K, Shaikh AA, Liu J, Gupta K, AbuSara N, Srivastava SK, Deng A, Rouah A, Swackhamer MJ.   +8 more
europepmc   +1 more source

Mobilome-mediated transcriptional activation of biosynthetic gene clusters and its impact on strain competitiveness in food fermentation microbiomes. [PDF]

Microbiome
Xu L, Jiao JY, Ling C, Du RB, Wu Q, Xu Y, Li WJ.   +6 more
europepmc   +1 more source

Regulatory Genes as Beacons for Discovery and Prioritization of Biosynthetic Gene Clusters in <i>Streptomyces</i>. [PDF]

Biochemistry
Augustijn HE, van Nassauw D, Cernat S, Reitz ZL, van Wezel GP, Medema MH.   +5 more
europepmc   +1 more source

plantiSMASH 2.0: improvements to detection, annotation, and prioritization of plant biosynthetic gene clusters

Del Pup E, Owen C, Luo Z, Augustijn HE, Draisma A, Polturak G, Kautsar SA, Osbourn A, van der Hooft JJ, Medema MH.   +9 more
europepmc   +1 more source

PathoFact 2.0: an integrative pipeline for the prediction of antimicrobial resistance genes, virulence factors, toxins and toxin-associated proteins, and biosynthetic gene clusters in metagenomes. [PDF]

Gigascience
Delgado LF, Ortís Sunyer J, Laczny CC, Hickl O, May P, Wilmes P.   +5 more
europepmc   +1 more source

PanBGC: a pangenome-inspired framework for comparative analysis of biosynthetic gene clusters. [PDF]

ISME Commun
Paccagnella D, Bağcı C, Gavriilidou A, Ziemert N.   +3 more
europepmc   +1 more source

Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential

Microorganisms, 2019
Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery.
D Cole Stevens, Barbara I Adaikpoh, Shukria Akbar   +2 more
exaly   +3 more sources

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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium

Mycotoxin Research, 2006
A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen, M, Schmidt-Heydt, A, Karolewiez   +2 more
openaire   +2 more sources

Characterization of the Actinonin Biosynthetic Gene Cluster

ChemBioChem, 2018
AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf, Franziska Leipoldt, Andreas Kulik, Daniel Wibberg, Jörn Kalinowski, Leonard Kaysser   +5 more
openaire   +2 more sources

Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi

Mycological Research, 2008
Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression
Ellen M, Fox, Barbara J, Howlett
openaire   +2 more sources