Results 251 to 260 of about 3,203,016 (289)
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Lessons from the rifamycin biosynthetic gene cluster
Current Opinion in Chemical Biology, 1999There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
H G, Floss, T W, Yu
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Cloning and Sequencing of the Chaetocin Biosynthetic Gene Cluster
ChemBioChem, 2013How a fungus does it: The epidithiodiketopiperazine (ETP) fungal alkaloids, which include gliotoxin, have garnered much attention since their initial isolation. The cloning and sequencing of the biosynthetic gene cluster for another ETP, chaetocin A were used to suggest a route towards dimerization and sulfur incorporation in these molecules.
Thomas, Gerken, Christopher T, Walsh
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Biosynthetic Gene Clusters in Bacteria: A Review
Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 2022Soil is a nutrient-rich environment that harbors billions of microbial species. The diversity of microbes in an environment varies with the change in edaphic factors. To survive these environmental changes, microbes produce secondary metabolites which are not directly associated with their growth and reproduction. Bacterial genomes possess biosynthetic
Rimsha Dilshad, Nazia Jamil, Rida Batool
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A Bioinformatics Workflow for Investigating Fungal Biosynthetic Gene Clusters
2022Predicting secondary metabolite biosynthetic gene clusters is a routine analysis performed for each newly sequenced fungal genome. Yet, the usefulness of such predictions remains restricted as they provide total numbers of biosynthetic pathways with only very limited biological significance.
Collemare, J., Navarro-Munoz, J.C.
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Nat. Prod. Rep., 2011
Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identiļ¬ed in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identiļ¬ed in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Characterization of the secondary metabolite biosynthetic gene clusters in archaea
Computational Biology and Chemistry, 2019Secondary metabolites are a range of bioactive compounds yielded by bacteria, fungi and plants, etc. The published archaea genomic data provide the opportunity for efficient identification of secondary metabolite biosynthetic gene clusters (BGCs) by genome mining. However, the study of secondary metabolites in archaea is still rare.
Shengqin Wang +4 more
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Advances in mining and expressing microbial biosynthetic gene clusters
Critical Reviews in Microbiology, 2023Zeling Xu, Huiluo Cao
exaly