Results 251 to 260 of about 99,198 (289)

Analysis of Co-localized Biosynthetic Gene Clusters Identifies a Membrane-Permeabilizing Natural Product. [PDF]

J Nat Prod
Chen X, Li B.
europepmc   +1 more source

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome. [PDF]

Nucleic Acids Res
Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz GP, Hegemann JD, Bozhüyük KAJ, Müller R, Keller A, Gurevich A.   +10 more
europepmc   +1 more source

Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing. [PDF]

Microorganisms
Tamang P, Upadhaya A, Paudel P, Meepagala K, Cantrell CL.   +4 more
europepmc   +1 more source

In silico exploration of biosynthetic gene clusters in marine Streptomyces sp. and Nocardiopsis sp. from the western coast of India: Genome-based profiling using whole genome sequencing. [PDF]

J Genet Eng Biotechnol
Kumar H, Vijayakumar S, Shintre N, Tamhane V, Deshpande N, Joshi T, Mathpal S, Anbarasu A, Ramaiah S.   +8 more
europepmc   +1 more source

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Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene

ChemBioChem, 2022
AbstractSalinipeptins belong to the type‐A linaridin class of ribosomally synthesized and post‐translationally modified peptides (RiPPs) comprising 22 amino acid residues with multiple D‐amino acids. Although chirality of other type‐A linaridins, such as grisemycin and cypemycin, has not been reported, the biosynthetic gene clusters of type‐A ...
Wanlu Xiao, Yasuharu Satoh, Yasushi Ogasawara, Tohru Dairi   +3 more
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Lessons from the rifamycin biosynthetic gene cluster

Current Opinion in Chemical Biology, 1999
There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
H G, Floss, T W, Yu
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Leveraging yeast to characterize plant biosynthetic gene clusters

Current Opinion in Plant Biology, 2023
Plant biosynthetic gene clusters (BGCs) contain multiple physically clustered non-homologous genes that encode enzymes catalyzing diverse reactions in one plant natural product biosynthetic pathway. A growing number of plant BGCs have emerged as an underlying resource for understanding plant specialized metabolism and evolution, but the ...
Yinan Wu, Franklin L. Gong, Sijin Li
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Inducing Global Expression of Actinobacterial Biosynthetic Gene Clusters

2022
Bacteria produce an impressive array of bioactive specialized metabolites, with Streptomyces (and the actinobacteria more generally) being unusually diverse and prolific producers. However, the biosynthetic potential of these organisms has yet to be fully explored, as many of the biosynthetic gene clusters that direct the synthesis of these natural ...
Meghan A, Pepler, Xiafei, Zhang, , Hindra, Marie A, Elliot   +3 more
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Characterization of the Actinonin Biosynthetic Gene Cluster

ChemBioChem, 2018
AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf, Franziska Leipoldt, Andreas Kulik, Daniel Wibberg, Jörn Kalinowski, Leonard Kaysser   +5 more
openaire   +2 more sources