Results 31 to 40 of about 1,707 (143)

Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation

Scientific Reports
Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for ...
Marcelo Larami Santoro, Ana Teresa Azevedo Sachetto, Jaqueline Gomes Rosa, Ricardo José Soares Torquato, Débora Andrade-Silva, Dilza Trevisan-Silva, Cynthia Zaccanini de Albuquerque, Solange M. T. Serrano, Vânia Gomes de Moura Mattaraia, Aparecida Sadae Tanaka, Maria Elisa Peichoto   +10 more
doaj   +1 more source

Crioconservación de toxoplasma gondii

Biomédica: revista del Instituto Nacional de Salud, 1992
Toxoplasma gondii fue crioconservado en nitrógeno líquido usando como preservativo glicerol al 10% con el fin de mantener el protozoo por un largo período de tiempo. El descongelamiento de T. gondii se llevó a cabo, cuando los parásitos fueron requeridos
Sofía Duque Beltrán, María Mercedes Santacruz Chaves, Augusto Corredor Arjona   +2 more
doaj   +1 more source

Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram‐Negative Bacterial Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The ethanolic leaf extract of Mouriri elliptica exhibited antibacterial and antibiofilm activities against multidrug‐resistant clinical isolates and enhanced the activity of ampicillin. Its diverse chemical profile and low acute toxicity support this Cerrado species as a promising source of natural antibacterial adjuvants. ABSTRACT Bacterial resistance
Talita Vilalva Freire, Ana Carolina de Freitas Marques, Valéria dos Santos Gonçalves, Iluska Senna Bonfá Moslaves, Mônica Cristina Toffoli‐Kadri, Arthur Feliciano Camargo da Silva, Martha Janete Giz, Patrícia de Oliveira Figueiredo, Ana Camila Micheletti, Nídia Cristiane Yoshida   +9 more
wiley   +1 more source

EFEITOS DO ENRIQUECIMENTO AMBIENTAL NA MATERNIDADE SOBRE O BEM-ESTAR DE CAMUNDONGOS CRIADOS EM BIOTÉRIO [PDF]

, 2015
Objetivou-se verificar os efeitos do enriquecimento ambiental (EA) sobre o bem-estar de camundongos em maternidade de um biotério. Para isso, camundongos Swiss da maternidade do biotério da Universidade Positivo foram separados ao acaso em dois grupos de
Deguchi, Bernardo Graça Fatori, Molento, Carla Forte Maiolino, Bones, Vanessa Carli, Medeiros, Hisly Any Stiegelmeier   +3 more
core   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Dual Beneficial Effects of Topical l‐Glutamine on Oral Mucositis in 5‐Fluorouracil‐Treated Mice

Journal of Oral Pathology &Medicine, Volume 55, Issue 6, Page 705-717, July 2026.
ABSTRACT Background Oral mucositis is a severe health and economic problem that occurs in about 40%–90% of patients undergoing cancer treatments. Systemic or topical application of l‐glutamine has been shown to improve mucosal healing and ameliorate oral mucositis (OM) symptoms according to clinical score systems.
Juliana Francisca Grossi Heleno, Igor de Campos Fontes, Leticia Cristine Cardoso dos Santos, Victor Prokop Gonçalves Campos, Iury Berckmann Freitas Gomes, Derek William Gilroy, Silvia Passos Andrade, Paula Peixoto Campos   +7 more
wiley   +1 more source

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

Aging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris, Nico Marx, Gonzalo Barrientos, Isidora Molina‐Riquelme, Frank Schmelter, Hugo E. Verdejo, Stefan Peischard, Guiscard Seebohm, Verónica Eisner, Karin B. Busch   +9 more
wiley   +1 more source

Cortisol influence on testicular testosterone secretion in domestic cat: An in vitro study Ação do cortisol sobre a secreção de testosterona em testículos de gato doméstico: um estudo in vitro

Pesquisa Veterinária Brasileira, 2010
The aim of the present experiment was to investigate the effect of corticosteroids (exogen) on in vitro testosterone secretion after stress by transportation (40 minutes).
Gelson Genaro, Celso R Franci
doaj   +1 more source

AAV‐Driven miR‐146a Promotes Neurite Outgrowth and Axonal Regeneration in Cortical Neurons

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
In the adult central nervous system (CNS), neuronal regeneration after injury is limited, resulting in poor functional recovery. MicroRNAs (miRNAs), a class of small noncoding RNAs that control gene expression, have gained attention as potential therapeutic agents, although their contribution to CNS repair remains insufficiently understood.
V. U. S. Matos, R. A. Almeida, C. G. Ferreira, M. T. R. Alves, M. P. Braga, M. C. Silva, T. F. da Silva, P. P. G. Guimarães, F. M. Soriani, P. Caramelli, M. R. Costa, U. Michel, V. T. Ribas   +12 more
wiley   +1 more source

Gangliosideos e a resposta de hipersensibilidade retardada em camundongos

Acta Cirúrgica Brasileira, 2000
Em trabalhos anteriores mostrou-se que os gangliosídeos (GSLs) têm um efeito inibitório sobre a proliferação linfocitária e a síntese de IL-2, assim como sobre a reação mista de linfócitos.
EFS MONTERO, LC CASTRO, K VON KOSSEL, MCB MANNA, MK KOIKE, DJ FAGUNDES, CL BARBIERI   +6 more
doaj   +1 more source