Results 21 to 30 of about 1,707 (143)

Evaluations of Anticancer Effects of Combinations of Cisplatin and Tirucallane‐Type Triterpenes Isolated from Amphipterygium adstringens (Schltdl).

open access: yesChemistry &Biodiversity, Volume 20, Issue 10, October 2023., 2023
Abstract The cytotoxic activity of combinations of masticadienonic (AMD) or 3αOH‐hydroxy‐masticadienonic (3αOH‐AMD) acids with cisplatin (CDDP) was evaluated against PC3 prostate and HCT116 colon cancer cell lines. Combinations A (half the IC50 value), B (IC50 value), and C (twice the IC50 value) were tested at a 1 : 1 ratio.
Lidia Díaz‐Sánchez   +5 more
wiley   +1 more source

Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity

open access: yesAging Cell, Volume 22, Issue 6, June 2023., 2023
Incubation of β‐cells with sera or plasma from obese rats and humans hampers mitochondrial oxidative phosphorylation and glucose‐stimulated insulin secretion (GSIS) relative to sera and plasma from lean rats and humans. Adiponectin, found at elevated levels in lean subjects, supports β‐cell function on its own, in the absence of sera, and also reverses
Ana Cláudia Munhoz   +8 more
wiley   +1 more source

Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients

open access: yesMolecular Oncology, Volume 16, Issue 9, Page 1913-1930, May 2022., 2022
Epigenetic alterations related to aberrant gene expression are important regulators of malignant transformation and melanoma progression. Here, we integrated transcriptome and methylome data from a linear model of murine melanoma progression and identified promoter and/or gene body DNA methylation profiles that induced gene expression changes related ...
Debora D’Angelo Papaiz   +12 more
wiley   +1 more source

Treatment with Distinct Antibiotic Classes Causes Different Pulmonary Outcomes on Allergic Airway Inflammation Associated with Modulation of Symbiotic Microbiota

open access: yesJournal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Background. Asthma is a chronic pulmonary disease that affects about 300 million people worldwide. Previous studies have associated antimicrobial use with allergies, but the real impact of antibiotics on asthma is still elusive. We investigated the potential impact of amoxicillin (Amox), trimethoprim/sulfamethoxazole (TMP/SMX), and metronidazole (Metro)
Gregório Grama Cavalcante   +11 more
wiley   +1 more source

Controle de animais de biotério [PDF]

open access: yes, 2021
Orientador: Profa. Dra. Rafaela Mantovani FontanaCoorientador:Monografia (especialização) - Universidade Federal do Paraná, Setor de ..., Curso de Especialização em ...Inclui referências: 67-68Resumo: Com as diversas atividades em andamento em um ...
Oliveira, Drielly Aparecida Souza Passos Minelli Lisboa de
core  

VALIDAÇÃO DO MODELO DE CAMUNDONGOS TRANSGÊNICOS COM ANEMIA FALCIFORME ADQUIRIDOS E CRIADOS NO BIOTÉRIO DO IGM/FIOCRUZ-BA

open access: yesHematology, Transfusion and Cell Therapy, 2023
A anemia falciforme (AF) é uma das doenças monogênicas hereditárias mais comum no mundo. Os indivíduos com AF apresentam diversas manifestações clínicas, como síndrome torácica aguda, acidente vascular cerebral, infecção, priapismo e úlcera de perna ...
SCMA Yahouédéhou   +6 more
doaj   +1 more source

Variações nos níveis das células sangüíneas periféricas encontradas em Holochilus brasiliensis nanus Thomas, 1897, infectados com Schistosoma mansoni Sambon, 1907, próprio da Pré-Amazônia Variations in peripheral blood cell levels examined in Schistosoma mansoni - infected Holochilus brasiliensis nanus Thomas, 1897, from lower Amazonia, Brazil

open access: yesRevista de Saúde Pública, 1985
Foram constituídos quatro grupos de roedores silvestres para a contagem de células sangüíneas periféricas, da seguinte forma: Grupo I - formado de animais normais, nascidos em biotério, com 30 dias de vida; Grupo II - formado de animais que foram ...
Othon de Carvalho Bastos   +3 more
doaj   +1 more source

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

open access: yesNature Communications, 2021
To date there is only one single drug with modest efficacy and no vaccine available to protect from schistosomiasis. Here, Amaral et al. characterize the self-cure process of rhesus macaques following primary infection and secondary challenge with ...
Murilo Sena Amaral   +18 more
doaj   +1 more source

Desarrollo embrionario del primer molar mandibular del ratón Mus musculus cepa albino suizo

open access: yesRevista de Ciencias, 2015
Objetivo: Describir el desarrollo embrionario del primer molar mandibular del ratón Mus musculus de la cepa albino suizo. Materiales y métodos: Estudio observacional de tipo descriptivo sobre el desarrollo embrionario del primer molar mandibular de ...
Jhon Aymer Díaz   +2 more
doaj   +1 more source

Medicina veterinária legal na criação e experimentação de animais de laboratório

open access: yesPubvet
Animais de laboratório são amplamente utilizados no ensino e nas pesquisas científicas. No entanto, não há como confiar nos dados científicos de atividades que utilizem animais com a saúde e bem-estar afetados, pois comprometem a validade dos dados das ...
Jackson Barros do Amaral   +2 more
doaj   +1 more source

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