Results 71 to 80 of about 1,603,318 (313)

Strategic planning for the development of industrial biotechnological enterprises

open access: yesПутеводитель предпринимателя, 2020
The role of biotechnology and biotechnology products in the development of the Russian economy as a whole was determined. A comprehensive model of the interconnection between the life cycles of biotechnologies and biotechnological products, as well as ...
A. S. Glazkova, V. A. Epifanov
doaj  

BIOTECHNOLOGY REVOLUTION AND POTENTIAL MILITARY APPLICATIONS

open access: yesAcademy Journal of Science and Engineering, 2022
In the 21st century, biotechnology is no doubt one of the fields in science and technology with the most developmental potential. Modern-day biotechnology is a multidisciplinary field where its utility has grown from traditional uses like agriculture and
N Egbe
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Biotechnology of Coconut

open access: yesJournal of Horticultural Sciences, 2007
Biotechnology of coconut (Cocos nucifera L.) is a relatively recent area compared to similar work in other crops. It started as tissue culture in the eighties, which led to the development of molecular markers in late nineties with the use of RAPDs ...
V A Parthasarathy   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Practicing environmental biotechnology

open access: yes上海师范大学学报. 自然科学版, 2014
Environmental biotechnology involves ″managing microbial communities to provide services to society″.Its success comes from partnering with prokaryotic microorganisms,whose wideranging metabolic capabilities can be harnessed to destroy pollutants and to
Bruce E.Rittmann
doaj   +1 more source

BIOTECHNOLOGY AND THE HUMAN GOOD

open access: yes, 2007
Preface -- Acknowledgments -- 1. The rapidly changing world of biotechnology -- 2. Humanity and the technological narrative -- 3. Biotechnology and competing worldviews -- 4. Biotechnology and human dignity -- 5.
Mitchell, C. Ben; Pellegrino, Edmund D.; Elshtain, Jean Bethke; Kilner, John F.; Rae, Scott B.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Perkembangan Bioteknologi di Indonesia

open access: yesRekayasa, 2019
Bioteknologi telah berkembang di Indonesia sejak lama namun cenderung lambat dikarenakan oleh beberapa faktor. Faktor pertama adalah minimnya dana penelitian dalam bidang bioteknologi.
Ummi Wasilah   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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