Results 91 to 100 of about 102,201 (258)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Protocol for the extraction and purification of shikimic acid from

STAR Protocols
Summary: Shikimic acid (SA) is a valuable pharmaceutical precursor used in drug synthesis. Here, we present a protocol for isolating and purifying SA from Escherichia coli cultures.
Pedro Silva, Ana C. Afonso, Manuel Simões, Lúcia Santos, Margarida M.S.M. Bastos   +4 more
doaj   +1 more source

Current research in biotechnology: Exploring the biotech forefront [PDF]

, 2019
Biotechnology is an evolving research field that covers a broad range of topics. Here we aimed to evaluate the latest research literature, to identify prominent research themes, major contributors in terms of institutions, countries/regions, and journals.
Silva A. S., Ibanez E., Cifuentes A., Banach M., Muller R., Gupta S. C., Bauer R., Orive G., Fiebich B., Gupta V. K., Perry G., Bishayee A., Diederich M., Gibbons S., Tzvetkov N. T., Orhan I. E., Aggarwal B. B., Weckwerth W., Efferth T., Russo G. L., Nicoletti F., Daglia M., Atanasov A. G., Macias F. A., Bonn G. K., Wolfender J. -L., Stadler M., Lizard G., Battino M., Yeung A. W. K., Heinrich M., Bayer E. A., Wink M., Ristow M., Verpoorte R., Xiao J., Huber L. A., Ibanez, Elena, Gibbons, Simon, Diederich, M, Perry, George, Stadler, M, Xiao, J, Fiebich, B, Weckwerth, Wolfram, Tzvetkov, Nikolay T., Diederich, Marc, Bishayee, A, Gupta, Vijai K., Yeung, AWK, Gupta, VK, Stadler, Marc, Lizard, Gérard, Nicoletti, F, Bayer, Edward A., Verpoorte, R, Weckwerth, W, Macias, Francisco A., Daglia, M, Wink, M, Cifuentes, Alejandro, Orhan, Ilkay Erdogan, Bonn, Günther K., Verpoorte, Robert, Silva, Ana Sanches, Wolfender, Jean-Luc, Silva, AS, Ibanez, E, Battino, Maurizio, Bonn, GK, Ristow, M, Lizard, G, Banach, Maciej, Yeung, Andy Wai Kan, Atanasov, Atanas G., Russo, GL, Macias, FA, Müller, R, Wink, Michael, Xiao, Jianbo, Nicoletti, Ferdinando, Bishayee, Anupam, Bauer, Rudolf, Gupta, SC, Battino, M, Russo, Gian Luigi, Atanasov, AG, Efferth, T, Müller, Rolf, Orive, Gorka, Gupta, Subash C., Huber, Lukas A., Efferth, Thomas, Bayer, EA, Tzvetkov, NT, Heinrich, M, Banach, M, Daglia, Maria, Ristow, Michael, Huber, LA, Orhan, IE, Gibbons, S, Heinrich, Michael, Orive, G, Cifuentes, A, Aggarwal, Bharat Bhushan, Bauer, R, Aggarwal, BB, Perry, G, Fiebich, Bernd, Wolfender, JL   +110 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Frontiers in Bioengineering and Biotechnology

Frontiers in Bioengineering and Biotechnology publishes articles across a wide research spectrum. The mission of the journal is to bring all relevant bioengineering and biotechnology areas together on a single ...
cristofolini luca
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Protocol for whole-tissue immunolabeling, optical clearing, and lightsheet imaging of c-Fos protein expression in unsectioned mouse brains

STAR Protocols
Summary: The c-Fos protein has been broadly utilized as a marker of neuronal activity, and conventional immunohistochemistry to determine its expression relies on tissue sections.
Koukou Fu, Jing Yang
doaj   +1 more source

Advances in Bioengineering [PDF]

, 2015
The technological approach and the high level of innovation make bioengineering extremely dynamic and this forces researchers to continuous updating. It involves the publication of the results of the latest scientific research.

core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Protocol to express anti-viral nanobodies and antigenic proteins anchored on the bacterial cell surface through the engineering of probiotic Escherichia coli Nissle 1917

STAR Protocols
Summary: Here, we present a protocol to express anti-viral nanobodies or antigenic proteins anchored on the bacterial cell surface through the engineering of probiotic E. coli Nissle 1917 (EcN).
Nitin S. Kamble, Abram Canowitz, Nathan Muck, Komalpreet Kaur, Nalinikanth Kotagiri   +4 more
doaj   +1 more source